Retest reliability of reward-related BOLD signals
Retest reliability of reward-related BOLD signals
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DOI：
10.1016/j.neuroimage.2010.01.036
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发表时间：
2010-04-15
期刊：
影响因子：
5.7
通讯作者：
Weber, Bernd
中科院分区：
文献类型：
--
作者：
Fliessbach, Klaus;Rohe, Tim;Weber, Bernd
奖励处理是学习和决策的核心组成部分。功能性磁共振成像（fMRI）为我们理解人类的奖励过程做出了重要贡献。与奖励相关的大脑反应的强度可能被证明是一个有价值的标记，或者与个人偏好或个性特征相关。一个必要的先决条件是奖励相关的大脑信号的个体测量的足够可靠性。因此，我们确定了BOLD反应的重测可靠性奖励预测，奖励接收和奖励预测错误的腹侧纹状体和眶额皮质在25名受试者经历三种不同的简单奖励范例（重测间隔7-13天）。尽管在组水平上，两个阶段的范式一致导致相关脑区的显著激活，但跨受试者的重测可靠性仅为差至中等（组内相关系数（ICC）为-0.15至0.44）。运动激活的ICC相当高（ICC 0.32至0.73）。我们的研究结果揭示了奖励加工的fMRI研究中跨学科相关性背后的方法学困难。这些结果表明，需要研究，解决方法，以优化重测可靠性的fMRI。(C)2010年爱思唯尔公司All rights reserved.
Reward processing is a central component of learning and decision making. Functional magnetic resonance imaging (fMRI) has contributed essentially to our understanding of reward processing in humans. The strength of reward-related brain responses might prove as a valuable marker for, or correlate of, individual preferences or personality traits. An essential prerequisite for this is a sufficient reliability of individual measures of reward-related brain signals. We therefore determined test-retest reliabilities of BOLD responses to reward prediction, reward receipt and reward prediction errors in the ventral striatum and the orbitofrontal cortex in 25 subjects undergoing three different simple reward paradigms (retest interval 7-13 days). Although on a group level the paradigms consistently led to significant activations of the relevant brain areas in two sessions, across-subject retest reliabilities were only poor to fair (with intraclass correlation coefficients (ICCs) of -0.15 to 0.44). ICCs for motor activations were considerably higher (ICCs 0.32 to 0.73). Our results reveal the methodological difficulties behind across-subject correlations in fMRI research on reward processing. These results demonstrate the need for studies that address methods to optimize the retest reliability of fMRI. (C) 2010 Elsevier Inc. All rights reserved.