Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles
Male age negatively impacts embryo development and reproductive outcome in donor oocyte assisted reproductive technology cycles
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DOI：
10.1016/j.fertnstert.2007.06.009
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发表时间：
2008-07-01
影响因子：
6.7
通讯作者：
Scott, Richard T., Jr.
中科院分区：
文献类型：
--
作者：
Frattarelli, John L.;Miller, Kathleen A.;Scott, Richard T., Jr.
目的：确定男性年龄是否影响辅助生殖技术周期中的胚胎发育和生殖潜力。设计：回顾性队列分析。地点：私人 IVF 中心。患者：1,023 名参与匿名卵母细胞捐赠周期的男性伴侣。干预措施：不孕夫妇接受 1,023 个匿名卵母细胞捐赠周期。主要结果指标：活产率。结果：流产率显着增加，活产率下降， 50 岁以上的男性中发现囊胚形成率下降。着床率、妊娠率或整个卵裂阶段的早期胚胎发育没有显着差异（通过受精率、胚胎卵裂率、未受精或多精胚胎的百分比、胚胎停滞率或第 3 天的七个或更多细胞胚胎发育来证明）。 45 岁以上的男性比 45 岁以上的男性拥有更多的精液量和更多的活动精子。精子形态或浓度没有显着变化。结论：在使用供体卵母细胞模型控制女性年龄后，男性年龄>50岁显着影响妊娠结局和囊胚形成率。精液量和总活力随着男性年龄的增加而下降。整个卵裂阶段的初始胚胎形态不受影响。
Objective: To determine whether male age influences embryo development and reproductive potential in assisted reproductive technology cycles.Design: Retrospective cohort analysis.Setting: Private IVF center.Patient(s): One thousand twenty-three male partners participating in anonymous oocyte donation cycles.Intervention(s): Infertile couples undergoing 1,023 anonymous oocyte donation cycles.Main Outcome Measure(s): Live birth rate.Result(s): A significant increase in pregnancy loss, decrease in live birth, rate, and decrease in blastocyst formation rate were noted in men >50 years of age. There was no significant difference in implantation rate, pregnancy rate, or early embryo development through the cleavage stage (demonstrated by fertilization rate, embryo cleavage rate, percentage of nonfertilized or polyspermic embryos, rate of embryo arrest, or seven or more cell embryo development on day 3). Men >= 45 years of age had significantly more semen volume and more motile sperm than men >45 years of age. There was no significant change in sperm morphology or concentration.Conclusion(s): After controlling for female age with use of the donor oocyte model, male age >50 years significantly affected pregnancy outcomes and blastocyst formation rates. Semen volume and total motility decreased with increasing male age. initial embryo morphology through the cleavage stage was not affected.