A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.
A new osteopetrosis mutant mouse strain (ntl) with odontoma-like proliferations and lack of tooth roots.
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DOI：
10.1111/j.1600-0722.2009.00690.x
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发表时间：
2009-12
影响因子：
1.9
通讯作者：
Feng JQ
中科院分区：
文献类型：
--
作者：
Lu X;Rios HF;Jiang B;Xing L;Kadlcek R;Greenfield EM;Luo G;Feng JQ
报道了一种新的常染色体隐性遗传性石骨症自发突变小鼠。这些小鼠形成了抗酒石酸盐酸性磷酸盐（TRAP）阳性破骨细胞，但它们的破骨细胞没有皱褶的边界，也没有吸收骨。这些小鼠未显示牙齿萌出或牙根形成。成年突变小鼠的门牙近端附近出现牙瘤样增生。腹膜内注射的祖细胞从肝脏的16.5天postcoplant野生型胚胎到新生儿突变体拯救了骨硬化症的表型，表明缺陷是内在的破骨细胞。我们的研究结果不仅进一步支持破骨细胞在牙齿萌出和牙根发育中的关键作用，而且还表明，扰动的牙源性前体的门牙的稳态是主要负责的牙瘤样增殖的发展，在这种骨硬化症突变。遗传作图已经将突变等位基因的位置缩小到小鼠17号染色体上3.2 cM的遗传间隔。
A new spontaneous mouse mutant (ntl) with autosomal-recessive osteopetrosis was characterized. These mice formed tartrate-resistant acid phosphate (TRAP)-positive osteoclasts but their osteoclasts had no ruffled border and did not resorb bone. These mice displayed no tooth eruption or tooth root formation. Adult mutant mice developed odontoma-like proliferations near the proximal ends of the incisors. Intraperitoneal injection of progenitor cells from the liver of 16.5 days postcoitum wild-type embryos into newborn mutants rescued the osteopetrosis phenotype, indicating that the defects were intrinsic to the osteoclasts. Our findings not only provide further support for a critical role of osteoclasts in tooth eruption and tooth root development, but also suggest that the perturbation of the homeostasis of the odontogenic precursors of the incisors is primarily responsible for the development of the odontoma-like proliferations in this osteopetrosis mutant. Genetic mapping has narrowed down the location of the mutant allele to a genetic interval of 3.2 cM on mouse chromosome 17.
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影响因子：
30.8
作者：
Luo, GB;Santoro, IM;Bradley, A
通讯作者：
Bradley, A
DOI：
10.1002/ajmg.1320340110
发表时间：
1989-09-01
期刊：
AMERICAN JOURNAL OF MEDICAL GENETICS
影响因子：
--
作者：
MARKS, SC
通讯作者：
MARKS, SC
血管内皮生长因子可以替代巨噬细胞集落刺激因子来支持破骨细胞骨吸收。
影响因子：
15.3
作者：
Niida, S;Kaku, M;Amano, H;Yoshida, H;Kataoka, H;Nishikawa, S;Tanne, K;Maeda, N;Nishikawa, S;Kodama, H
通讯作者：
Kodama, H
影响因子：
3.5
作者：
Kornak, U;Schulz, A;Kubisch, C
通讯作者：
Kubisch, C
影响因子：
10.5
作者：
Lomaga, MA;Yeh, WC;Mak, TW
通讯作者：
Mak, TW