Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?
Plant phytochemicals as new potential drugs for immune disorders and cancer therapy: really a promising path?
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DOI：
10.1002/jsfa.5670
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发表时间：
2012-06-01
影响因子：
4.1
通讯作者：
Chirumbolo, Salvatore
中科院分区：
文献类型：
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作者：
Chirumbolo, Salvatore
植物植物化学物质代表了一个令人兴奋的机会，通过平衡和适当管理的日常营养或膳食补充剂来保持最佳健康状况，并且通常被认为是从植物中获得一些有前途的昂贵新药的良好选择。几种多酚化合物，如白藜芦醇、茶儿茶素和类黄酮，通常存在于蔬菜、水果和植物来源的果汁或饮料中，具有充分证明的心脏保护、神经保护、化学预防和抗炎特性，但仍需要进一步的临床和流行病学研究。大多数这些植物副产品是由植物产生的有害成分，以防止病原体定植，昆虫介导的损害，并阻止动物食用它们。压力适应的进化理论可以解释这些来自自然界的有毒物质如何作为保护分子。一个未来的挑战，以实现一个相当完整的了解这些化学苯酚衍生物对人类健康的处理细胞信号网络的复杂性，细胞的表观遗传机械禀赋和剂量和有效性之间的非线性关系。版权所有（c）2012化学工业协会
Plant phytochemicals represent an exciting opportunity to maintain best health conditions through a balanced and properly administered daily nutrition or dietary supplement and have often been considered a good option for obtaining a few promising, expensive new drugs from plants. Several polyphenolic compounds, such as resveratrol, tea catechins and flavonoids, which are commonly found in vegetables, fruits and plant-derived juices or beverages, exert well-evidenced cardioprotective, neuroprotective, chemopreventive and anti-inflammatory properties, but, nevertheless, further clinical and epidemiological research is required. Most of these botanical byproducts are produced as noxious components by plants, in order to prevent pathogen colonization, insect-mediated damage and also to discourage animals from eating them. An evolutionary theory of stress adaptation would explain how these toxic substances from nature act as protective molecules. A future challenge to achieve a rather complete understanding of these chemical phenol derivatives for human health should deal with the complexity of cellular signalling networks, the epigenetic machinery endowment of the cell and the nonlinear relationship between dose and effectiveness. Copyright (c) 2012 Society of Chemical Industry