Types or States? Cellular Dynamics and Regenerative Potential.
Types or States? Cellular Dynamics and Regenerative Potential.
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DOI：
10.1016/j.tcb.2015.07.008
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发表时间：
2015-11
影响因子：
19
通讯作者：
Sánchez Alvarado A
中科院分区：
文献类型：
--
作者：
Adler CE;Sánchez Alvarado A
由于组织特异性的多能干细胞的作用，我们的许多器官可以在动态平衡和损伤期间保持和修复自己。然而，最近来自哺乳动物系统的证据表明，损伤刺激干细胞和更多分化细胞的显著可塑性或细胞潜力的瞬时变化。扁虫拥有丰富的干细胞，这使它们成为了解体内平衡和再生背后的细胞行为的特殊模型。最近对细胞谱系和再生特异性事件的发现为解开复杂的细胞对再生的贡献提供了一个初步的框架。在这篇综述中，我们讨论了在脊椎动物再生的背景下细胞可塑性的概念，并考虑了多能性可能是干细胞表现出的一种瞬时的、概率的状态。
Many of our organs can maintain and repair themselves during homeostasis and injury, due to the action of tissue-specific, multipotent stem cells. However, recent evidence from mammalian systems suggests that injury stimulates dramatic plasticity, or transient changes in cell potential, in both stem cells and more differentiated cells. Planarian flatworms possess abundant stem cells, making them an exceptional model for understanding the cellular behavior underlying homeostasis and regeneration. Recent discoveries of cell lineages and regeneration-specific events provide an initial framework for unraveling the complex cellular contributions to regeneration. In this review we discuss the concept of cellular plasticity in the context of planarian regeneration, and consider the possibility that pluripotency may be a transient, probabilistic state exhibited by stem cells.