Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach.
Changes in EEG complexity with electroconvulsive therapy in a patient with autism spectrum disorders: a multiscale entropy approach.
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DOI：
10.3389/fnhum.2015.00106
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发表时间：
2015
影响因子：
2.9
通讯作者：
Wada Y
中科院分区：
文献类型：
--
作者：
Okazaki R;Takahashi T;Ueno K;Takahashi K;Ishitobi M;Kikuchi M;Higashima M;Wada Y
自闭症谱系障碍（ASD）是异质性神经发育障碍，据报道其特征在于异常的神经网络。近年来发展起来的多尺度熵分析（MSE）可以刻画神经网络动力学中多个时间尺度上脑电动力学的复杂性。我们遇到了一个18岁的男性ASD患者，他的顽固性紧张性强迫症状在电休克治疗（ECT）后得到了显着改善。在这个临床病例研究中，我们试图通过使用MSE评估EEG复杂性来阐明ASD中ECT的神经生理机制。沿着ECT，额中央区在较高的时间尺度上表现出降低的EEG复杂性，而枕区在较低的时间尺度上表现出增加。此外，这些变化与脑源性神经营养因子升高相关的临床改善相关，脑源性神经营养因子是ECT的分子假设，在ASD发病机制中起关键作用。我们发现，在特定区域和时间尺度特定的方式，脑电复杂性的变化可能反映了非典型的脑电动力学ASD。虽然MSE不是测量神经连接的直接方法，并且结果仅来自单个病例，但它们可能反映了ASD中特定的异常神经网络活动和ECT的治疗神经生理学机制。
Autism spectrum disorders (ASD) are heterogeneous neurodevelopmental disorders that are reportedly characterized by aberrant neural networks. Recently developed multiscale entropy analysis (MSE) can characterize the complexity inherent in electroencephalography (EEG) dynamics over multiple temporal scales in the dynamics of neural networks. We encountered an 18-year-old man with ASD whose refractory catatonic obsessive–compulsive symptoms were improved dramatically after electroconvulsive therapy (ECT). In this clinical case study, we strove to clarify the neurophysiological mechanism of ECT in ASD by assessing EEG complexity using MSE. Along with ECT, the frontocentral region showed decreased EEG complexity at higher temporal scales, whereas the occipital region expressed an increase at lower temporal scales. Furthermore, these changes were associated with clinical improvement associated with the elevation of brain-derived neurotrophic factor, which is a molecular hypothesis of ECT, playing key roles in ASD pathogenesis. Changes in EEG complexity in a region-specific and temporal scale-specific manner that we found might reflect atypical EEG dynamics in ASD. Although MSE is not a direct approach to measuring neural connectivity and the results are from only a single case, they might reflect specific aberrant neural network activity and the therapeutic neurophysiological mechanism of ECT in ASD.
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影响因子：
--
作者：
Remijnse, Peter L.;Nielen, Marjan M. A.;Veltman, Dick J.
通讯作者：
Veltman, Dick J.
影响因子：
4.7
作者：
Fosse R;Read J
通讯作者：
Read J
影响因子：
4.7
作者：
Jelles, B.;Scheltens, Ph.;Stam, C. J.
通讯作者：
Stam, C. J.
DOI：
10.1016/j.clinph.2010.03.025
发表时间：
2010-09
期刊：
Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology
影响因子：
--
作者：
Mizuno T;Takahashi T;Cho RY;Kikuchi M;Murata T;Takahashi K;Wada Y
通讯作者：
Wada Y
影响因子：
4.7
作者：
Catarino, Ana;Churches, Owen;Ring, Howard
通讯作者：
Ring, Howard