Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study
Maternal immune markers during pregnancy and child neurodevelopmental outcomes at age 20 months in the Seychelles Child Development Study
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DOI：
10.1016/j.jneuroim.2019.577023
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发表时间：
2019-10-15
影响因子：
3.3
通讯作者：
van Wijngaarden, Edwin
中科院分区：
文献类型：
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作者：
Irwin, Jessica L.;McSorley, Emeir M.;van Wijngaarden, Edwin
怀孕期间的免疫失调可能会影响后代的行为和神经发育，但很少有人类研究证实了这一假设。使用结构方程模型，我们研究了1453对母子样本中妊娠28周的母亲炎症标志物与20个月大的儿童神经发育结局之间的关系。我们观察到在妊娠中期晚期或妊娠晚期早期测量的母体炎症标志物与儿童神经发育结局之间的几种关联。一些标记的关联方向是出乎意料的。需要进一步的研究来证实和阐明这些发现的确切性质。
Immune dysregulation during pregnancy may influence behavior and neurodevelopment in offspring, but few human studies have tested this hypothesis. Using structural equation modeling, we examined associations between maternal inflammatory markers at 28 weeks gestation and child neurodevelopmental outcomes at 20 months of age in a sample of 1453 mother-child pairs. We observed several associations between maternal inflammatory markers measured in the late second or early third trimester and child neurodevelopmental outcomes. The direction of association for some markers was unexpected. Further research is warranted to confirm and elucidate the exact nature of these findings.