Interaction of Helicobacter pylori with Genetic Variants in the MDM2 Promoter, is Associated with Gastric Cancer Susceptibility in Chinese Patients
Interaction of Helicobacter pylori with Genetic Variants in the MDM2 Promoter, is Associated with Gastric Cancer Susceptibility in Chinese Patients
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幽门螺杆菌与 MDM2 启动子遗传变异的相互作用与中国患者胃癌易感性相关
DOI：
10.1111/j.1523-5378.2009.00712.x
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发表时间：
2009-10-01
期刊：
影响因子：
4.4
通讯作者：
Zhang, Guoxin
中科院分区：
文献类型：
--
作者：
Wang, Xiaoyong;Yang, Jing;Zhang, Guoxin
背景和目的：MDM 2是p53的主要负调控因子，MDM 2启动子区SNP 309（rs 2279744）的单核苷酸多态性（SNP）已被证明可增加转录激活因子Sp1的亲和力，导致MDM 2在某些癌症中的转录和表达升高。方法：采用PCR-RFLP方法对260例胃癌患者和260例健康对照者进行MDM 2SNP 309基因分型。结果：健康对照组在所研究的多态位点（KH）处于Hard-Weinberg平衡
Background and Aims:MDM2 is a major negative regulator of p53, and a single nucleotide polymorphism (SNP) in the MDM2 promoter region SNP309 (rs2279744) has been shown to increase the affinity of the transcriptional activator Sp1, resulting in elevated MDM2 transcription and expression in some cancers. The aim of this study was to determine whether SNP309 is associated with susceptibility to gastric cancer in Chinese patients.Methods:Two hundred and sixty patients with gastric cancer and 260 healthy controls were genotyped for MDM2 SNP309 using the PCR-RFLP method. Helicobacter pylori's infection status was determined using a validated serology test.Results:The healthy control group was found to be in Hard-Weinberg equilibrium at the polymorphic loci studied (KH