The lncRNAs involved in regulating the RIG-I signaling pathway.
The lncRNAs involved in regulating the RIG-I signaling pathway.
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DOI：
10.3389/fcimb.2022.1041682
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发表时间：
2022
影响因子：
5.7
通讯作者：
中科院分区：
文献类型：
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作者：
了解与视黄酸诱导基因-I（RIG-I）信号通路相关的长链非编码RNA（lncRNA）的靶点和相互作用对于开发干预措施至关重要，这将使宿主炎症反应调节能够导向保护性免疫。在RIG-I信号通路中，lncRNA参与泛素化、磷酸化和糖酵解的重要过程，从而促进干扰素调节因子3和7（IRF 3和IRF 7）以及核因子κ B（NF-κB）转运到细胞核中，并激活I型干扰素（IFN-I）和炎症因子向抗病毒作用位点的募集。此外，最近有报道称RIG-I信号通路包含冠状病毒疾病-19（COVID-19）相关lncRNA的靶标。RIG-I信号通路中的分子直接受lncRNA-microRNA（miRNAs）-信使RNA（mRNA）轴调节。因此，靶向该轴已成为诊断和治疗癌症的新策略。本文就lncRNA在病毒感染和癌症中对RIG-I信号通路的调控进行了综述。目的是为今后进一步开展lncRNA和RIG-I的详细研究提供坚实的信息基础，并为临床药物开发做出贡献。
Understanding the targets and interactions of long non-coding RNAs (lncRNAs) related to the retinoic acid-inducible gene-I (RIG-I) signaling pathway is essential for developing interventions, which would enable directing the host inflammatory response regulation toward protective immunity. In the RIG-I signaling pathway, lncRNAs are involved in the important processes of ubiquitination, phosphorylation, and glycolysis, thus promoting the transport of the interferon regulatory factors 3 and 7 (IRF3 and IRF7) and the nuclear factor kappa B (NF-κB) into the nucleus, and activating recruitment of type I interferons (IFN-I) and inflammatory factors to the antiviral action site. In addition, the RIG-I signaling pathway has recently been reported to contain the targets of coronavirus disease-19 (COVID-19)-related lncRNAs. The molecules in the RIG-I signaling pathway are directly regulated by the lncRNA–microRNAs (miRNAs)–messenger RNA (mRNA) axis. Therefore, targeting this axis has become a novel strategy for the diagnosis and treatment of cancer. In this paper, the studies on the regulation of the RIG-I signaling pathway by lncRNAs during viral infections and cancer are comprehensively analyzed. The aim is to provide a solid foundation of information for conducting further detailed studies on lncRNAs and RIG-I in the future and also contribute to clinical drug development.
谷氧还蛋白/S-谷胱甘肽轴调节肺上皮细胞中白细胞介素 17A 诱导的促炎症反应，与核因子 κB 家族蛋白的 S-谷胱甘肽化相关。
影响因子：
7.4
作者：
Nolin, James D.;Tully, Jane E.;Hoffman, Sidra M.;Guala, Amy S.;van der Velden, Jos L.;Poynter, Matthew E.;van der Vliet, Albert;Anathy, Vikas;Janssen-Heininger, Yvonne M. W.
通讯作者：
Janssen-Heininger, Yvonne M. W.