Prognostic value of lymphocyte-to-monocyte ratio and systemic immune-inflammation index in non-small-cell lung cancer patients with brain metastases
Prognostic value of lymphocyte-to-monocyte ratio and systemic immune-inflammation index in non-small-cell lung cancer patients with brain metastases
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DOI：
10.2217/fon-2020-0423
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发表时间：
2020-10-01
期刊：
影响因子：
3.3
通讯作者：
Yu, Jinming
中科院分区：
文献类型：
--
作者：
Li, Aijie;Mu, Xiangkui;Yu, Jinming
目的：本研究旨在评价非小细胞肺癌（NSCLC）脑转移患者外周血嗜中性粒细胞/淋巴细胞比值（NLR）、血小板/淋巴细胞比值（PLR）、淋巴细胞/单核细胞比值（LMR）和全身免疫炎症指数（SII）的预后价值。材料与方法：采用Kaplan-Meier分析和多因素考克斯分析，评价NLR、PLR、LMR和SII对预后的影响。结果：Kaplan-Meier分析显示低LMR、高NLR、PLR和SII组患者的总生存期较短。多变量考克斯分析显示LMR和SII是总生存期的独立预后因素（分别为p = 0.002和p = 0.004）。结论：LMR和SII对非小细胞肺癌脑转移患者的临床预后评估有重要价值。
Aim: We aimed to evaluate the prognostic values of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR) and systemic immune-inflammation index (SII) in patients with brain metastases from non-small-cell lung cancer (NSCLC). Materials & methods: We conducted Kaplan-Meier analysis and multivariable Cox analysis to evaluate the prognostic values of NLR, PLR, LMR and SII. Results: Kaplan-Meier analysis showed that the patients in low LMR, high NLR, PLR and SII groups were associated with shorter overall survival. Multivariable Cox analysis revealed LMR and SII were independent prognostic factors for overall survival (p = 0.002 and p = 0.004, respectively). Conclusion: LMR and SII are of significant values in clinical prognostic evaluation for patients with brain metastases from NSCLC.