Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication.
Initial experience with SPECT (single-photon computerized tomography) of the brain using N-isopropyl I-123 p-iodoamphetamine: concise communication.
复制标题
使用 N-异丙基 I-123 对碘苯丙胺进行大脑 SPECT（单光子计算机断层扫描）的初步经验：简洁的沟通。
DOI：
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发表时间：
1982
影响因子：
9.3
通讯作者：
A. M. BaldwIn
中科院分区：
文献类型：
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作者：
T. Hill;B. LeonardHolman;R. Lovett;D. O'leary;D. Front;P. Magistretti;R. Zimmerman;S. Moore;MeMn E. Clouse;J. Wu;T. Lin;A. M. BaldwIn
46例患者接受了N-异丙基-I-123对碘苯丙胺(IMP)和哈佛扫描多探测器脑系统的研究。在9例对照患者中，大脑皮质和基底节的灰质和白质分化良好。局部摄取受生理动作(视觉刺激)的影响。在24例卒中患者中，IMP图像显示8例首次透射式计算机断层扫描(TCT)正常的急性脑梗塞受累区域；10例IMP显示的血流灌注异常大于TCT异常。24例患者中有23例出现血流灌注异常。有TIA病史的7名患者的TCT和IMP图像正常。在三名癫痫发作活动期患者中，高灌注区与脑电癫痫灶相对应。3例脑肿瘤患者活动性明显降低，与TCT上的局灶性异常相对应。我们的研究证明了使用一种脂溶的、在脑中有高提取分数的放射性药物与单光子ECT一起评估局部脑血流灌注的可行性。
Forty-six patients were studied with N-isopropyl I-123 p-iodoamphetamine (IMP) and the Harvard Scanning Multidetector Brain System. In nine control patients, good differentiation between the gray and white matter of the cerebral cortex and the basal ganglia was evident. Regional uptake was affected by physiologic maneuvers (visual stimulation). In 24 patients studied for stroke, IMP images demonstrated areas that were involved in acute infarction in eight patients whose initial transmission computerized tomography (TCT) was normal; IMP also showed perfusion abnormalities larger than the TCT abnormality in ten patients. Perfusion abnormalities were present in 23/24 of these patients. Seven patients studied with a history of TIA had normal TCT and IMP images. In three patients studied during seizure activity, regions of hyperperfusion corresponded to the EEG seizure focus. Markedly decreased activity was present in three patients with brain tumor and corresponded to the focal abnormality on the TCT study. Our study demonstrates the feasibility of assessing regional brain perfusion using a radiopharmaceutical that is lipid soluble and has a high extraction fraction in the brain, together with single-photon ECT.