Carotid wall viscosity increase is related to intima-media thickening in hypertensive patients
Carotid wall viscosity increase is related to intima-media thickening in hypertensive patients
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DOI：
10.1161/01.hyp.31.1.534
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发表时间：
1998-01-01
期刊：
影响因子：
8.3
通讯作者：
Levenson, J
中科院分区：
文献类型：
--
作者：
Armentano, RL;Graf, S;Levenson, J
高血压患者存在动脉壁粘度和内膜中层厚度（IMT）的增加，由于平滑肌细胞负责动脉壁的粘性行为，并参与内膜中层复合体的增厚过程，本研究评价了颈动脉厚度与壁粘度的关系。使用高分辨率超声对内膜-中膜复合体和动脉直径波形进行同步和无创评估。本研究对11例正常血压者（NTA）和11例轻中度原发性高血压（HTA）患者的颈总动脉进行了无创性测量，并对B型图像进行自动密度分析，获得IMT和瞬时压力及直径环。粘弹性模型用于推导壁粘度指数（η），使用滞后回线消除标准。在NTA中，eta为2.73 +/-1.66（mm Hg. s/mm）和IMT为0.58 ± 0.08（mm），而HTA的eta为5.91 ± 2.34（P
Increases in arterial wall viscosity and intima-media thickness (IMT) were found in hypertensive patients, Because smooth muscle cells are responsible for the viscous behavior of the arterial wall and they are involved in the process of thickening of the intima-media complex, this study evaluates the relationship between carotid thickness and wall viscosity. The simultaneous and noninvasive assessment of the intima-media complex and arterial diameter waveform was performed using high-resolution ultrasonography. This technique was contrasted against sonomicrometry in sheep, showing that the waveforms obtained by both methods were similar, The common carotid arteries of 11 normotensive subjects (NTA) and 11 patients with mild to moderate essential hypertension (HTA) were measured noninvasively by using tonometry and an automatic densitometric analysis of B-mode images to obtain IMT and instantaneous pressure and diameter loops. A viscoelastic model was used to derive the wall viscosity index (eta) using the hysteresis loop elimination criteria. In NTA, eta was 2.73+/-1.66 (mm Hg . s/mm) and IMT was 0.58+/-0.08 (mm), whereas in HTA, eta was 5.91+/-2.34 (P