Homocysteine, malondialdehyde and endothelial markers in dialysis patients during low-dose folinic acid therapy
Homocysteine, malondialdehyde and endothelial markers in dialysis patients during low-dose folinic acid therapy
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DOI：
10.1046/j.1365-2796.2002.01056.x
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发表时间：
2002-11-01
影响因子：
11.1
通讯作者：
Strandjord, RE
中科院分区：
文献类型：
--
作者：
Apeland, T;Mansoor, MA;Strandjord, RE
目标。血液透析患者的致动脉粥样硬化氨基酸同型半胱氨酸水平升高。我们想要评估小剂量静脉注射亚叶酸（叶酸的活性形式）对心血管疾病的一些生化危险因素的影响。设计。纵向和开放的干预研究。设置。罗加兰县的两个透析单位。受试者。所有接受维持性血液透析的患者都被邀请，35 名患者中有 32 名给出了知情同意书。干预措施。每次透析结束后，患者静脉注射亚叶酸1.0 mg，每周三次，持续3个月。在研究之前和研究期间，所有患者均接受小剂量维生素 B1、B2、B3、B5、B 6 和 B12 的维持补充。主要结果指标。 (1) 血浆总同型半胱氨酸 (p-tHcy) 和叶酸，(ii) 循环内皮相关蛋白（内皮活化标志物）和 (iii) 血清丙二醛 (S-MDA)（氧化应激和脂质过氧化标志物）水平的变化。结果。 p-tHcy 水平降低了 37%（P
Objectives. Haemodialysis patients have elevated levels of the atherogenic amino acid homocysteine. We wanted to assess the effects of small doses of intravenous folinic acid (the active form of folic acid) on some biochemical risk factors of cardiovascular disease.Design. Longitudinal and open intervention study.Setting. Two dialysis units in the County of Rogaland.Subjects. All patients on maintenance haemodialysis were invited, and 32 of 35 patients gave their informed consent.Interventions. After each dialysis session, the patients were given 1.0 mg of folinic acid intravenously thrice a week for a period of 3 months. Prior to and during the study, all patients were on maintenance supplementation with small doses of vitamins B1, B2, B3, B5, B 6 and B12.Main outcome measures. Changes in the levels of (1) plasma total homocysteine (p-tHcy) and folate, (ii) circulating endothelium related proteins-markers of endothelial activation and (iii) serum malondialdehyde (S-MDA)-a marker of oxidative stress and lipid peroxidation.Results. The p-tHcy levels were reduced by 37% (P