Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
Regulatory roles of cyclin dependent kinase phosphorylation in cell cycle control
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DOI：
10.1016/s0955-0674(96)80080-9
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发表时间：
1996-12-01
影响因子：
7.5
通讯作者：
Kornbluth, S
中科院分区：
文献类型：
--
作者：
Lew, DJ;Kornbluth, S
细胞周期蛋白和细胞周期蛋白依赖性激酶（Cdks）是真核细胞中细胞周期进程的普遍调节因子。Cdk的活性由三个保守位点的磷酸化控制，许多作用于这些位点的酶现已被鉴定。虽然Cdk磷酸化的生物化学是相对较好的理解，这种磷酸化的调节作用，在许多情况下，模糊不清。最近的研究发现了新的和意想不到的潜在作用，并促使重新审查以前假设的作用，Cdk磷酸化。
Cyclins and cyclin-dependent kinases (Cdks) are universal regulators of cell cycle progression in eukaryotic cells. Cdk activity is controlled by phosphorylation at three conserved sites, and many of the enzymes that act on these sites have now been identified. Although the biochemistry of Cdk phosphorylation is relatively well understood, the regulatory roles of such phosphorylation are, in many cases, obscure. Recent studies have uncovered new and unexpected potential roles, and prompted re-examination of previously assumed roles, of Cdk phosphorylation.