Smokers with airway obstruction are more likely to quit smoking
Smokers with airway obstruction are more likely to quit smoking
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DOI：
10.1136/thx.2006.059071
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发表时间：
2006-10-01
期刊：
影响因子：
10
通讯作者：
Zielinski, J.
中科院分区：
文献类型：
--
作者：
Bednarek, M.;Gorecka, D.;Zielinski, J.
背景：慢性阻塞性肺疾病（COPD），通常由吸烟引起，是发病率和死亡率的主要原因之一。在疾病的早期阶段戒烟通常会阻止疾病的进一步发展。进行了一项研究，以确定是否诊断为气道阻塞与随后的成功戒烟，建议由一个physician.Methods：4494目前吸烟者（57.4%的男性）的历史，至少10包年的吸烟招募100 000名受试者筛选肺功能测试的迹象，气道阻塞。在筛选时，所有人都接受了简单的戒烟建议。1177例（26.2%）受试者患有气道阻塞，并被告知他们患有COPD，戒烟将阻止其肺部疾病的快速进展。未拟定药物治疗。1年后，邀请所有受试者进行随访访视。吸烟状态进行了评估的历史和验证呼出的一氧化碳level.Results：近70%参加了后续访问（n = 3077）：61%是男性，平均（SD）年龄为52（10）岁，平均（SD）烟草暴露30（17）包年，和33.3%的气道阻塞在基线检查。经验证，呼吸道阻塞患者的戒烟率为16.3%，而肺功能参数正常者的戒烟率为12.0%（p = 0.0003）。校正后的年龄，性别，尼古丁依赖，每天吸烟的香烟数量，肺功能，成功戒烟预测较低的肺功能，较低的尼古丁依赖，和较低的烟草exposed.Conclusions：简单的戒烟建议结合肺功能检测导致良好的1年戒烟率，特别是在气道阻塞的受试者。
Background: Chronic obstructive pulmonary disease ( COPD), usually caused by tobacco smoking, is one of the leading causes of morbidity and mortality. Smoking cessation at an early stage of the disease usually stops further progression. A study was undertaken to determine if diagnosis of airway obstruction was associated with subsequent success in smoking cessation, as advised by a physician.Methods: 4494 current smokers (57.4% men) with a history of at least 10 pack-years of smoking were recruited from 100 000 subjects screened by spirometric testing for signs of airway obstruction. At the time of screening all received simple smoking cessation advice. 1177 (26.2%) subjects had airway obstruction and were told that they had COPD and that smoking cessation would halt rapid progression of their lung disease. No pharmacological treatment was proposed. After 1 year all subjects were invited for a follow up visit. Smoking status was assessed by history and validated by exhaled carbon monoxide level.Results: Nearly 70% attended a follow up visit (n = 3077): 61% were men, mean (SD) age was 52 ( 10) years, mean ( SD) tobacco exposure 30 ( 17) pack-years, and 33.3% had airway obstruction during the baseline examination. The validated smoking cessation rate in those with airway obstruction was 16.3% compared with 12.0% in those with normal spirometric parameters ( p = 0.0003). After correction for age, sex, nicotine dependence, number of cigarettes smoked daily, and lung function, success in smoking cessation was predicted by lower lung function, lower nicotine dependence, and lower tobacco exposure.Conclusions: Simple smoking cessation advice combined with spirometric testing resulted in good 1 year cessation rates, especially in subjects with airway obstruction.