Structure and modulation of Fc and complement receptors.
Structure and modulation of Fc and complement receptors.
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Fc 和补体受体的结构和调节。
DOI：
10.1007/978-1-4757-4862-8_6
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Wright,SD
中科院分区：
文献类型：
--
作者：
Unkeless,JC;Wright,SD
Metchnikoff（1987）首先观察到的专业吞噬细胞的一个显著特征是它们结合和摄取外来颗粒的能力。在执行这一重要任务时，多形核白细胞（PMN）或巨噬细胞必须首先识别入侵者。细胞完成这种识别的机制，对于许多粒子，如乳胶或碳，还不是很清楚，并且可能不是通过粒子与受体的相互作用进行的。另一方面，许多高度危险的颗粒，如细菌和酵母，在调理素的帮助下被识别，调理素是一种特异性结合入侵者作为吞噬信号的蛋白质（Griffin, 1977）。摄取这些调理素包被的颗粒是通过与细胞膜上特定的糖蛋白受体相互作用触发的。本章专门讨论受体介导的吞噬作用。
A striking feature of the professional phagocytes first observed by Metchnikoff (I887) is their ability to bind and ingest foreign particles. In carrying out this vital task, the polymorphonuclear leukocyte (PMN) or macrophage must first recognize the intruder. The mechanism by which cells accomplish this recognition is, for many particles such as Latex or carbon, not well understood, and may not proceed through interaction of the particle with a receptor. On the other hand, many highly dangerous particles, such as bacteria and yeast, are recognized with the aid of opsonins-proteins that bind specifically to the intruder as a signal for phagocytosis (Griffin, 1977). Ingestion of these opsonin-coated particles is triggered by interaction with specific glycoprotein receptors on the cell plasma membrane. This chapter addresses exclusively receptor-mediated phagocytosis.