Mumps vaccination coverage and vaccine effectiveness in a large outbreak among college students - Iowa, 2006
Mumps vaccination coverage and vaccine effectiveness in a large outbreak among college students - Iowa, 2006
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DOI：
10.1016/j.vaccine.2008.04.075
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发表时间：
2008-07-04
期刊：
影响因子：
5.5
通讯作者：
LeBaron, Charles W.
中科院分区：
文献类型：
--
作者：
Marin, Mona;Quinlisk, Patricia;LeBaron, Charles W.
在实施常规的儿童两剂麻疹-腮腺炎-风疹疫苗接种策略后，美国的腮腺炎发病率急剧下降，并设定了2010年消除腮腺炎的目标。然而，2006年的一次疫情涉及全国超过5700例病例，其中许多报告发生在完全接种疫苗的大学生中。在爱荷华州的两所大学爆发的疫情中，我们调查了：（1）通过提供者记录验证的电子记录的疫苗接种覆盖率;（2）通过比较特定剂量的攻击率评估的疫苗有效性。流行性腮腺炎分为典型（腮腺炎/睾丸炎）或非典型（腮腺压痛或下颌下/舌下腺炎）。学生人群（2128/2363）和病例学生（97/108）的两剂流行性腮腺炎疫苗接种覆盖率均为90%。两剂疫苗的有效性为76-88%，一剂和两剂之间的发病率没有显著差异。在接种两剂疫苗的人群中，74%的人群（1482/2009）和79%的病例学生（75/95）在> 10年前接种过第二剂疫苗。两剂疫苗的有效性与以前的一剂疫苗的估计值相似。需要进一步的研究来检查两剂腮腺炎疫苗诱导的免疫力的持久性，并确定美国腮腺炎是否可以通过目前的疫苗接种策略消除。出版社：Elsevier Ltd
Following implementation of a routine childhood two-dose measles-mumps-rubella vaccination strategy, mumps disease levels dropped dramatically in the US and an elimination goal was set for 2010. However, a 2006 epidemic involved >5700 cases nationwide, with many reported among fully vaccinated college students.In an outbreak in two Iowa colleges, we investigated: (1) vaccination coverage using electronic records verified by provider records and (2) vaccine effectiveness assessed by comparison of dose-specific attack rates. Mumps was classified as typical (parotitis/orchitis) or atypical (parotid tenderness or submandibular/sublingual adenitis).Two-dose mumps vaccination coverage was 90% both for the student population (2128/2363) and case-students (97/108). Two-dose vaccine effectiveness was 76-88% with no significant difference for attack rates between one and two doses. Among two-dose vaccine recipients, 74% of the population (1482/2009) and 79% of the case-students (75/95) had received the second dose >10 years before.A large mumps outbreak occurred despite high two-dose vaccination coverage in a population most of whom had received the second dose >10 years before. Two-dose vaccine effectiveness was similar to previous one-dose estimates. Further studies are needed to examine the persistence of two-dose mumps vaccine-induced immunity and to determine whether US mumps elimination can be achieved with the current vaccination strategy. Published by Elsevier Ltd.