Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study
Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study
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DOI：
10.1007/s10552-010-9658-7
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发表时间：
2010-12-01
影响因子：
2.3
通讯作者：
Webb, Penelope M.
中科院分区：
文献类型：
--
作者：
Fearnley, Emily J.;Marquart, Louise;Webb, Penelope M.
目的虽然多囊卵巢综合征（PCOS）是子宫内膜癌的危险因素，但目前支持的流行病学证据非常有限。我们的目的是评估PCOS，PCOS症状，子宫内膜癌的风险之间的关联，在妇女年龄小于50 years.Methods数据来自全国人口为基础的病例对照研究在澳大利亚。新诊断的组织学确诊的子宫内膜癌病例通过澳大利亚各地的治疗诊所和癌症登记处确定。对照组是从全国选民名册中随机挑选的。女性接受了关于其生殖和病史的采访，包括自我报告的PCOS和生活方式。目前的分析仅限于50岁以下的妇女（156例，398对照）。我们估计优势比（OR）使用逻辑回归调整混杂factors.Results妇女与PCOS有四倍增加子宫内膜癌的风险相比，妇女没有PCOS（OR 4.0，95%CI 1.7-9.3）。当额外校正体重指数时，这种关联减弱（OR 2.2，95% CI 0.9-5.7）。当仅限于I型癌症时，风险略高。PCOS症状，包括多毛症和非常不规则的时期显着相关的子宫内膜癌risk.Conclusions这些数据扩展了现有的研究结果，包括调整混杂因素，表明PCOS是子宫内膜癌的危险因素。
Objective Although polycystic ovary syndrome (PCOS) is commonly cited as a risk factor for endometrial cancer, supporting epidemiological evidence is currently very limited. Our aim was to assess the associations between PCOS, PCOS symptoms, and risk of endometrial cancer in women aged less than 50 years.Methods Data came from a national population-based case-control study in Australia. Cases with newly diagnosed histologically confirmed endometrial cancer were identified through treatment clinics and cancer registries Australia wide. Controls were randomly selected from the national electoral roll. Women were interviewed about their reproductive and medical history, including self-reported PCOS, and lifestyle. Current analyses were restricted to women aged under 50 (156 cases, 398 controls). We estimated odds ratios (OR) using logistic regression to adjust for confounding factors.Results Women with PCOS had a fourfold increased risk of endometrial cancer compared to women without PCOS (OR 4.0, 95% CI 1.7-9.3). This association was attenuated when additionally adjusted for body mass index (OR 2.2, 95% CI 0.9-5.7). Risk was slightly greater when restricted to Type I cancers. PCOS symptoms including hirsutism and very irregular periods were significantly associated with endometrial cancer risk.Conclusions These data extend existing findings, including adjustment for confounders, suggesting PCOS is a risk factor for endometrial cancer.