Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients.
Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients.
复制标题
喂养和假喂养对对照受试者和十二指肠溃疡患者血清胃泌素和胃酸分泌的影响。
DOI：
10.1080/00365521.1974.12096899
复制
发表时间：
1974
影响因子：
1.9
通讯作者：
W. Creutzfeldt
中科院分区：
文献类型：
--
作者：
G. Mayer;R. Arnold;G. Feurle;K. Fuchs;H. Ketterer;Track Ns;W. Creutzfeldt
Mayer, G.、Arnold, R.、Feurle, G.、Fuchs, K.、Ketterer, H.、Track, N. S. 和 Creutzfeldt, W. 喂养和假喂养对对照受试者和十二指肠溃疡患者血清胃泌素和胃酸分泌的影响。扫描。 J. Gastroent.1974,9, 703–710. 在标准流质餐后，十二指肠溃疡 (DU) 患者的血清免疫反应性胃泌素 (1RG) 水平显着高于健康对照，而空腹水平没有差异。改良的假喂养（MSF）程序定期刺激 DU 患者和对照组的胃酸分泌。 DU 患者对 MSF 的平均血清 IRG 反应明显高于对照组的轻微反应。对于 DU 患者进食或无国界医生治疗后 IRG 释放增加没有明显的解释。在 DU 患者和对照中，未发现胃酸对 MSF 的反应与 IRG 输出之间存在相关性。结果表明，人类迷走神经刺激后的酸分泌主要是通过对壁细胞的直接作用来实现的，并且迷走神经释放的IRG对迷走神经刺激后的酸分泌量没有显着贡献。
Mayer, G., Arnold, R., Feurle, G., Fuchs, K., Ketterer, H., Track, N. S. & Creutzfeldt, W. Influence of feeding and sham feeding upon serum gastrin and gastric acid secretion in control subjects and duodenal ulcer patients.Scand. J. Gastroent.1974,9, 703–710.Serum immunoreactive gastrin (1RG) levels increased significantly more, after a standard liquid meal, in duodenal ulcer (DU) patients than in healthy controls, while fasting levels did not differ. A modified sham feeding (MSF) procedure regularly stimulated gastric acid secretion both in DU patients and controls. The mean serum IRG response of DU patients to MSF was significantly greater than the slight response of the controls. There is no obvious explanation for the increased IRG release after feeding or MSF in DU patients. No correlation was found between the gastric acid response to MSF and the IRG output in DU patients and controls. The results suggest that acid secretion after vagal stimulation in man is mainly achieved by direct effects upon the parietal cells, and that vagally released IRG does not contribute significantly to the amount of acid secreted after vagal stimulation.