GLIAL CYTOPLASMIC INCLUSIONS IN THE CNS OF PATIENTS WITH MULTIPLE SYSTEM ATROPHY (STRIATONIGRAL DEGENERATION, OLIVOPONTOCEREBELLAR ATROPHY AND SHY-DRAGER SYNDROME)
GLIAL CYTOPLASMIC INCLUSIONS IN THE CNS OF PATIENTS WITH MULTIPLE SYSTEM ATROPHY (STRIATONIGRAL DEGENERATION, OLIVOPONTOCEREBELLAR ATROPHY AND SHY-DRAGER SYNDROME)
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DOI：
10.1016/0022-510x(89)90219-0
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发表时间：
1989-12-01
影响因子：
4.4
通讯作者：
LANTOS, PL
中科院分区：
文献类型：
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作者：
PAPP, MI;KAHN, JE;LANTOS, PL
用银染、免疫细胞化学和电子显微镜观察了11例纹状体黑质变性、橄榄桥小脑萎缩和Shy-Drager综合征患者的中枢神经系统(CNS)内的胶质细胞胞质包涵体(GCIS)。尽管它们在光学显微镜下的形态有时类似于神经原纤维缠结，但它们的细胞定位、测量、超微结构、免疫细胞化学特征和区域分布都不同于这些阿尔茨海默型变化。大多数GCIS定位于白质，并伴有束间少突胶质细胞数量增加和髓鞘染色苍白或消失。我们的组织学、超微结构和免疫细胞化学结果都表明，含有GCIS的细胞是少突胶质细胞，包涵体本身由管状结构组成。在所有11个中枢神经系统中均存在未知的GCI，但在年龄和性别匹配的对照脑中未发现GCI，这表明GCI是一种以多系统萎缩为特征的细胞变化，三个证候是同一疾病的不同表现。
Glial cytoplasmic inclusions (GCIs) were demonstrated by silver staining, immunocytochemistry and by electron microscopy in the central nervous system (CNS) of 11 patients with various combinations of striatonigral degeneration, olivopontocerebellar atrophy and Shy-Drager syndrome. Although their configuration in light microscope can sometimes resemble neurofibrillary tangles, their cellular localisation, measurements, ultrastructure, immunocytochemical characteristics and regional distribution all differ from these Alzheimer type changes. The majority of GCIs were localized in the white matter and appeared to be accompanied by an increase in the number of interfascicular oligodendroglial cells and pallor or loss of myelin staining. Our histological, ultrastructural and immunocytochemical findings all indicate that the cells which contain GCIs are oligodendrocytes and the inclusions themselves are composed of tubular structures. The presence of the until now unknown GCIs in all the 11 CNS, but not in age- and sex-matched control brains, indicates that GCI is a cellular change characteristic of multiple system atrophy and the three syndromes are various manifestations of the same disease.