Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy
Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy
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DOI：
10.1073/pnas.0901592106
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发表时间：
2009-04-07
影响因子：
11.1
通讯作者：
Frechet, Jean M. J.
中科院分区：
文献类型：
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作者：
Broaders, Kyle E.;Cohen, Joel A.;Frechet, Jean M. J.
结合了易合成、降解速率简单调节、可加工性和生物相容性的材料在生物医学应用中有着很高的需求。我们报道了乙酰化葡聚糖，一种生物相容性材料，可以形成微颗粒，降解率可调超过2个数量级取决于程度和类型的缩醛改性。在主要组织相容性复合体I类（MHC I）和MHC II呈现分析中，改变降解率产生的颗粒比聚乳酸-羟基乙酸和氧化铁（两种常用的用于颗粒免疫治疗的材料）表现更好。调节材料特性通过依赖或独立于与抗原加工相关的转运蛋白的途径导致抗原在MHC I上的递呈。据我们所知，这是唯一的例子，一种材料，可以调整操作在不同的免疫途径，同时最大限度地提高免疫表现。
Materials that combine facile synthesis, simple tuning of degradation rate, processability, and biocompatibility are in high demand for use in biomedical applications. We report on acetalated dextran, a biocompatible material that can be formed into microparticles with degradation rates that are tunable over 2 orders of magnitude depending on the degree and type of acetal modification. Varying the degradation rate produces particles that perform better than poly(lactic-co-glycolic acid) and iron oxide, two commonly studied materials used for particulate immunotherapy, in major histocompatibility complex class I (MHC I) and MHC II presentation assays. Modulating the material properties leads to antigen presentation on MHC I via pathways that are dependent or independent of the transporter associated with antigen processing. To the best of our knowledge, this is the only example of a material that can be tuned to operate on different immunological pathways while maximizing immunological presentation.