Assessment of the antiproliferative activity on murine melanoma cells of extracts from elicited cell suspensions of strawberry, strawberry tree, blackberry and red raspberry
Assessment of the antiproliferative activity on murine melanoma cells of extracts from elicited cell suspensions of strawberry, strawberry tree, blackberry and red raspberry
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DOI：
10.1080/11263504.2015.1018981
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发表时间：
2016-01-01
期刊：
影响因子：
2
通讯作者：
Caboni, E.
中科院分区：
文献类型：
--
作者：
Forni, C.;Frattarelli, A.;Caboni, E.
研究了草莓（Fragaria x ananassa Duch.）黑莓（Rubus fruticosus L.），红树莓（Rubus idaeus L.）和草莓（Arbutus unedo L.）对鼠B16-F10黑色素瘤细胞的作用。为了增强生物活性化合物的合成，还将各种诱导剂，即温度（冷和冷/暖循环）、光（蓝色和红色）和增加的氮浓度应用于细胞培养物，以评估对其抗增殖活性的影响。来自所有物种的提取物减少鼠黑素瘤细胞增殖（相对于对照在30%和38%之间），并且相对于未引发的浆果悬浮液，来自草莓和草莓树细胞的提取物显示出对鼠黑素瘤细胞的抗增殖活性的改善，所述草莓和草莓树细胞用红光和蓝光处理。
The antiproliferative activity of extracts from cell suspensions of strawberry (Fragaria x ananassa Duch.), blackberry (Rubus fruticosus L.), red raspberry (Rubus idaeus L.) and strawberry-tree (Arbutus unedo L.) on murine B16-F10 melanoma cells was investigated. To enhance the synthesis of the bioactive compounds, various elicitors, i.e. temperature (cold and cold/warm cycle), light (blue and red) and increased nitrogen concentration, were also applied to the cell cultures to evaluate the effects on their antiproliferative activity. The extracts from all the species reduced murine melanoma cell proliferation (between 30% and 38% relative to the control) and an improvement of antiproliferative activity on murine melanoma cells, relative to the un-elicited berry suspensions, was shown by the extracts from strawberry and strawberry-tree cells treated with red and blue light.