Environmental RNA interference in animals
Environmental RNA interference in animals
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DOI：
10.1007/s11434-013-5982-0
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发表时间：
2013-08
影响因子：
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通讯作者：
Lingfeng Meng;Liang Chen;Zhaoyong Li;Zhengxing Wu;G. Shan
中科院分区：
文献类型：
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作者：
Lingfeng Meng;Liang Chen;Zhaoyong Li;Zhengxing Wu;G. Shan
动物一直与环境相互作用，必须对环境中存在的各种因素做出反应。环境RNA干扰是指外源RNA分子可以进入某些动物物种的细胞并干扰这些动物的基因表达的现象。这些外源RNA可能是动物食物中的分子，也可能存在于生活环境中的其他来源。环境RNA进入细胞的分子途径及其在基因干扰中的功能已经开始在秀丽隐杆线虫动物模型中被揭示。在这里，我们强调了一些已知的环境RNA干扰（RNAi）在动物中的例子，并介绍其分子机制。
Animals interact with their environments all the time, and must react to all kinds of factors present in the environments. Environmental RNA interference refers to the phenomenon that exogenous RNA molecules can enter cells of certain animal species and interfere with gene expression of these animals. These exogenous RNAs may be molecules in animal food, or may be present in the living environment from other sources. Molecular pathways for the cell entry of environmental RNAs and further for their functionality in gene interference have started to be revealed in the animal modelCaenorhabditis elegans. Here we highlight some known examples of environmental RNA interference (RNAi) in animals and introduce the molecular mechanisms underneath.