Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: The Pan-Asia Menopause (PAM) study
Estradiol, FSH and LH profiles in nine ethnic groups of postmenopausal Asian women: The Pan-Asia Menopause (PAM) study
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DOI：
10.1080/13697130701610780
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发表时间：
2007-10-01
期刊：
影响因子：
2.8
通讯作者：
Holinka, C. F.
中科院分区：
文献类型：
--
作者：
Ausmanas, M. K.;Tan, D. A.;Holinka, C. F.
目的在参与泛亚更年期(PAM)研究的9个民族的绝经后亚洲妇女中，绝经症状和血脂谱的患病率有显著差异。基于这些发现，我们在PAM研究中验证了生殖激素谱在9个民族之间存在差异的假设。方法在中心实验室采用电化学发光免疫分析方法对9个民族的1020名绝经后妇女的基线血清样本进行分析。结果研究人群的激素水平(均值+SD)分别为：E2=74.1+/-125.1 pmol/L(n=1015)，FSH=81.2+/-31.4IU/L(n=1013)，LH=36.8+/-15.6IU/1(n=1015)。朝鲜族妇女雌二醇水平为50.0pmol/L，越南妇女为106.8 pmol/L，朝鲜族妇女为68.2IU/l，马来族妇女为90.8IU/L，黄体生成素水平为30.7IU/L，马来族妇女为44.1IU/l。Log E_2与FSH水平呈负相关，FSH与LH水平呈正相关。调整年龄和体重指数后，雌二醇、卵泡刺激素和促黄体生成素的浓度与种族显著相关。此外，3种激素水平与体重指数显著相关，而雌二醇和黄体生成素水平与年龄相关，而卵泡刺激素水平与年龄无关。结论亚洲绝经后妇女FSH、黄体生成素尤其是雌二醇水平在不同民族间存在显著差异。这些差异的临床意义，如果有的话，仍有待调查。E_2和FSH水平的负相关表明，绝经后状态的E_2仍然影响脑垂体FSH的输出。
Objectives Significant differences in the prevalence of menopausal symptoms and in lipid profiles have previously been reported for nine ethnic groups of postmenopausal Asian women participating in the Pan-Asia Menopause (PAM) study. Based on these findings, we tested the hypothesis that reproductive hormone profiles differ among the nine ethnic groups under investigation in the PAM study.Methods Baseline serum samples from postmenopausal women (n = 1020) representing nine ethnic groups were analyzed at a central laboratory by electro-chemiluminescence immunoassay methods. Hormone concentrations were measured for estradiol (E2), follicle stimulating hormone (FSH) and luteinizing hormone (LH).Results The hormone levels for the overall study population (mean + SD) were: E2 = 74.1 +/- 125.1 pmol/l (n = 1015); FSH = 81.2 +/- 31.4 IU/l (n = 1013); LH = 36.8 +/- 15.6 IU/1 (n = 1015). Estradiol levels ranged from 50.0 pmol/l in Chinese women to 106.8 pmol/l in Vietnamese women; FSH ranged from 68.2 IU/1 in Korean women to 90.8 IU/l in Malay women; and LH ranged from 30.7 IU/l in Korean women to 44.1 IU/1 in Malay women. There was an inverse correlation between log E2 and FSH levels and a positive correlation between FSH and LH levels. The concentrations of E2, FSH and LH were significantly associated with ethnicity after adjustment for age and body mass index. Additionally, the concentrations of all three hormones were significantly associated with body mass index, whereas E2 and LH levels were associated with age, but FSH levels were not.Conclusion The levels of FSH, LH and particularly of E2 differ substantially among ethnic groups of postmenopausal Asian women. The clinical significance, if any, of these differences remains to be investigated. The inverse correlation of E2 and FSH levels suggests that E2 at the postmenopausal state still affects pituitary FSH output.