Hair Follicle Stem Cells for Tissue Regeneration.
Hair Follicle Stem Cells for Tissue Regeneration.
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DOI：
10.1089/ten.teb.2021.0098
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发表时间：
2021-07
期刊：
影响因子：
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通讯作者：
Alyssa Peterson;Lakshmi R Nair
中科院分区：
文献类型：
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作者：
Alyssa Peterson;Lakshmi R Nair
随着目前处于临床前和临床研究中的各种细胞疗法的积极结果，人们对具有独特治疗特性的新型干细胞来源产生了极大的兴趣。在过去的二十年左右的研究证明了从毛囊中分离多能/多能干细胞的可行性。毛囊干细胞（hair follicle stem cells，HFSCs）具有易于获得、增殖和分化能力强以及不存在伦理问题等优点，是细胞治疗和组织工程的理想候选细胞。这篇综述讨论了在啮齿动物和人类毛囊中鉴定的各种干细胞类型，以及正在进行的关于HFSCs在皮肤、骨、心血管和神经组织工程中的潜在用途的研究。
With the positive outcomes of various cell therapies currently under pre-clinical and clinical studies, there is a significant interest in novel stem cell sources with unique therapeutic properties. Studies over the past two decades or so demonstrated the feasibility to isolate multipotent/pluripotent stem cells from hair follicles. The easy accessibility, high proliferation and differentiation ability as well as lack of ethical concerns associated with this stem cell source make hair follicle stem cells (HFSCs) attractive candidate for cell therapy and tissue engineering. This review discusses the various stem cell types identified in rodent and human hair follicles and ongoing studies on the potential use of HFSCs for skin, bone, cardio-vascular, and nerve tissue engineering.