Globus Sensation and Psychopathology in Men: The Vietnam Experience Study
Globus Sensation and Psychopathology in Men: The Vietnam Experience Study
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DOI：
10.1097/psy.0b013e3181bc7739
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发表时间：
2009-11-01
影响因子：
3.3
通讯作者：
Deary, Ian J.
中科院分区：
文献类型：
--
作者：
Gale, Catharine R.;Wilson, Janet A.;Deary, Ian J.
目的：探讨男性脑球是否与精神病理相关。长期以来，gtobuss一直被认为是一种主要是女性的疾病，它是一种没有可检测到的生理原因的喉咙肿块的持续感觉。几项完全或主要以女性为研究对象的小型研究表明，球状体与较高水平的抑郁、焦虑和躯体担忧有关。方法：参与者为4240名美国男性退伍军人，他们在中年时接受了详细的医学和心理检查。采用结构化诊断访谈和明尼苏达多相人格量表（MMPI）进行心理健康评估。MMPI包括一个关于全球存在的项目。结果：globus的患病率为6.4%。患有globus的男性被诊断为躯体化障碍的风险增加，优势比(OR) = 5.92, 95%可信区间(CI) = 3.22, 10.91；重度抑郁症，OR = 4.98, 95% CI = 3.63, 6.67；广泛性焦虑障碍，OR = 3.70, 95%, CI = 2.75, 4.90；创伤后应激障碍，OR = 3.50, 95% CI = 2.54, 4.76；药物滥用或依赖，or = 1.89, 95% CI = 1.15, 3.13；他们在10个MMPI临床量表中的9个得分明显更高。Globus还与较低的认知能力、社会经济和教育劣势、较高的脉搏率以及服用抗高血压药物的可能性增加有关。结论：Globus与男性广泛的精神病理有关，尤其是抑郁症和躯体化障碍。表现为球状球体的男性可能已经发展出这种特殊症状，以“代表”其他相关的、可治疗的精神病理，这也应该进行调查。
Objective: To assess whether globus is associated with psychopathology in men. Gtobus-a persistent sensation of having a lump in the throat with no detectable physical cause-has long been thought a predominantly female disorder. Several small studies, based wholly or largely on women, suggested that globus is associated with higher levels of depression, anxiety, and somatic concern. Methods: Participants were 4240 male U.S. veterans who underwent detailed medical and psychological examinations in middle age. Psychological health was assessed by structured diagnostic interview and the clinical scales of the Minnesota Multiphasic Personality Inventory (MMPI). The MMPI includes an item on the presence of globus. Results: The prevalence of globus was 6.4%. Men with globus had an increased risk of being diagnosed with somatization disorder, odds ratio (OR) = 5.92, 95% Confidence Interval (CI) = 3.22, 10.91; major depression, OR = 4.98, 95% CI = 3.63, 6.67; generalized anxiety disorder, OR = 3.70, 95%, CI = 2.75, 4.90; posttraumatic stress disorder, OR = 3.50, 95% CI = 2.54, 4.76; and drug abuse or dependence, OR = 1.89, 95% CI = 1.15, 3.13; and they scored significantly higher on nine of the ten MMPI clinical scales. Globus was also associated with lower cognitive ability, socioeconomic and educational disadvantage, a higher pulse rate, and increased likelihood of being on antihypertensive medication. Conclusions: Globus is linked with a wide range of psychopathology in men, notably depression and somatization disorder. Men presenting with globus might have developed that particular symptom to "represent" other, related and treatable psychopathology, which should also be investigated.