Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae
Regulation of forward and backward locomotion through intersegmental feedback circuits in Drosophila larvae
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DOI：
10.1038/s41467-019-10695-y
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发表时间：
2019-06-14
影响因子：
16.6
通讯作者：
Nose, Akinao
中科院分区：
文献类型：
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作者：
Kohsaka, Hiroshi;Zwart, Maarten F.;Nose, Akinao
动物运动需要全身肌肉在时空上协调收缩。在这里，我们调查如何收缩拮抗组肌肉intersegmentally协调在双向爬行的果蝇幼虫。我们确定了两对高阶运动前兴奋性中间神经元存在于每个腹部神经节，intersegmentally提供反馈给相邻的神经节在运动传播。这两个反馈神经元对在向前或向后运动期间是有差异地活跃的，但通常以一组运动前中间神经元为目标，这些中间神经元一起向横向肌肉提供兴奋性输入，并向拮抗性纵向肌肉提供抑制性输入。任何一对反馈神经元的抑制都会以方向特异性的方式损害横肌的收缩。我们的研究结果表明，节段间反馈神经元协调协同肌肉的收缩，作为延迟电路代表段之间的相位滞后。所识别的电路架构还显示了双向运动网络如何经济地嵌入神经系统。
Animal locomotion requires spatiotemporally coordinated contraction of muscles throughout the body. Here, we investigate how contractions of antagonistic groups of muscles are intersegmentally coordinated during bidirectional crawling of Drosophila larvae. We identify two pairs of higher-order premotor excitatory interneurons present in each abdominal neuromere that intersegmentally provide feedback to the adjacent neuromere during motor propagation. The two feedback neuron pairs are differentially active during either forward or backward locomotion but commonly target a group of premotor interneurons that together provide excitatory inputs to transverse muscles and inhibitory inputs to the antagonistic longitudinal muscles. Inhibition of either feedback neuron pair compromises contraction of transverse muscles in a direction-specific manner. Our results suggest that the intersegmental feedback neurons coordinate contraction of synergistic muscles by acting as delay circuits representing the phase lag between segments. The identified circuit architecture also shows how bidirectional motor networks could be economically embedded in the nervous system.