Hypothalamic orexin neurons regulate arousal according to energy balance in mice
Hypothalamic orexin neurons regulate arousal according to energy balance in mice
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DOI：
10.1016/s0896-6273(03)00331-3
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发表时间：
2003-06-05
期刊：
影响因子：
16.2
通讯作者：
Sakurai, T
中科院分区：
文献类型：
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作者：
Yamanaka, A;Beuckmann, CT;Sakurai, T
哺乳动物对食物供应减少的反应是变得更加清醒和活跃，但根据稳态需要调节唤醒和本能运动程序（如寻找食物）的中枢通路还没有得到很好的理解。我们证明，下丘脑食欲素神经元监测能量平衡指标，并介导响应禁食的觉醒的适应性增强。分离的食欲素神经元的活性被葡萄糖和瘦素抑制，并被ghrelin刺激。正常和肥胖基因突变小鼠的食欲素表达与血糖、瘦素和食物摄入的变化呈负相关。食欲素神经元被切除的转基因小鼠对禁食没有反应，觉醒和活动增加。这些发现表明食欲素神经元在能量平衡和觉醒之间提供了至关重要的联系。
Mammals respond to reduced food availability by becoming more wakeful and active, yet the central pathways regulating arousal and instinctual motor programs (such as food seeking) according to homeostatic need are not well understood. We demonstrate that hypothalamic orexin neurons monitor indicators of energy balance and mediate adaptive augmentation of arousal in response to fasting. Activity of isolated orexin neurons is inhibited by glucose and leptin and stimulated by ghrelin. Orexin expression of normal and ob/ob mice correlates negatively with changes in blood glucose, leptin, and food intake. Transgenic mice, in which orexin neurons are ablated, fail to respond to fasting with increased wakefulness and activity. These findings indicate that orexin neurons provide a crucial link between energy balance and arousal.