Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.
Three new dioxopiperazine metabolites from a marine-derived fungus Aspergillus fumigatus Fres.
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DOI：
10.1080/14786410902726134
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发表时间：
2010-05
影响因子：
2.2
通讯作者：
W. Zhao;T. Zhu;Guotao Fan;H. Liu;Yuchun Fang;Q. Gu;Weiming Zhu
中科院分区：
文献类型：
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作者：
W. Zhao;T. Zhu;Guotao Fan;H. Liu;Yuchun Fang;Q. Gu;Weiming Zhu
从海洋源性真菌烟曲霉 Fres 中分离出三种新的二氧代哌嗪代谢物 (1-3) 以及两种已知化合物 N-乙酰酪胺 (4) 和环-(Ala-Val) (5)。它们的结构是通过光谱方法确定的。通过磺基罗丹明B（SRB）方法初步评估了它们对K562细胞系的细胞毒活性。
Three new dioxopiperazine metabolites (1–3), together with two known compounds, N-acetyltyramine (4) and cyclo-(Ala-Val) (5), were isolated from a marine-derived fungus Aspergillus fumigatus Fres. Their structures were established by spectroscopic methods. Their cytotoxic activities against the K562 cell line were preliminarily evaluated by the sulphorhodamine B (SRB) method.