Rest boosts the long-term retention of spatial associative and temporal order information
Rest boosts the long-term retention of spatial associative and temporal order information
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DOI：
10.1002/hipo.22424
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发表时间：
2015-09-01
期刊：
影响因子：
3.5
通讯作者：
Wolbers, Thomas
中科院分区：
文献类型：
--
作者：
Craig, Michael;Dewar, Michaela;Wolbers, Thomas
如果人们在学习后休息几分钟，他们会比专注于新信息的人至少在7天内记住更多的新语言片段信息。据推测，休息可以更好地巩固新的记忆。在啮齿动物中，休息期促进海马体对最近旅行的路线的回放，这种回放被认为对记忆巩固和随后的空间导航至关重要。如果休息通过促进海马体重放/巩固来增强人类记忆，那么休息的有益效果应该延伸到复杂的(海马体)记忆任务，例如，探测关联和序列的任务。我们通过一个虚拟现实路径记忆任务来研究这个问题。健康的年轻参与者学习了两条达到100%标准的路线。其中一条路线之后是10分钟的休息，另一条路线之后是10分钟的差异游戏。对于每条学习的路线，参与者进行了四项延迟的空间记忆测试：(I)联想(地标方向)记忆，(Ii)认知地图形成，(Iii)时间(地标)顺序记忆，和(Iv)路线记忆。7天后重复测试，以确定任何长期影响。在路线记忆或认知地图测试中没有检测到休息的影响，很可能分别是由于天花板和地板的影响。然而，休息确实提高了在联想记忆和时序记忆测试中的保持能力，而且这种提高至少持续了7天。因此，我们证明休息的好处延伸到人类的(空间)联想和时间顺序记忆。我们假设，REST允许对与最近学习到的路线有关的新信息进行更好的巩固/海马体重放，从而在长期内增强新的记忆。(C)2015年威利期刊公司。
People retain more new verbal episodic information for at least 7 days if they rest for a few minutes after learning than if they attend to new information. It is hypothesized that rest allows for superior consolidation of new memories. In rodents, rest periods promote hippocampal replay of a recently travelled route, and this replay is thought to be critical for memory consolidation and subsequent spatial navigation. If rest boosts human memory by promoting hippocampal replay/consolidation, then the beneficial effect of rest should extend to complex (hippocampal) memory tasks, for example, tasks probing associations and sequences. We investigated this question via a virtual reality route memory task. Healthy young participants learned two routes to a 100% criterion. One route was followed by a 10-min rest and the other by a 10-min spot the difference game. For each learned route, participants performed four delayed spatial memory tests probing: (i) associative (landmark-direction) memory, (ii) cognitive map formation, (iii) temporal (landmark) order memory, and (iv) route memory. Tests were repeated after 7 days to determine any long-term effects. No effect of rest was detected in the route memory or cognitive map tests, most likely due to ceiling and floor effects, respectively. Rest did, however, boost retention in the associative memory and temporal order memory tests, and this boost remained for at least 7 days. We therefore demonstrate that the benefit of rest extends to (spatial) associative and temporal order memory in humans. We hypothesise that rest allows superior consolidation/hippocampal replay of novel information pertaining to a recently learned route, thus boosting new memories over the long term. (c) 2015 Wiley Periodicals, Inc.