The relationship between longitudinal change in pulmonary function and nonspecific airway responsiveness in children and young adults.
The relationship between longitudinal change in pulmonary function and nonspecific airway responsiveness in children and young adults.
复制标题
儿童和年轻人肺功能纵向变化与非特异性气道反应性之间的关系。
DOI：
10.1164/ajrccm/140.1.179
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Weiss,ST
中科院分区：
文献类型：
--
作者：
Redline,S;Tager,IB;Segal,MR;Gold,D;Speizer,FE;Weiss,ST
对184名儿童和年轻人进行了为期12年的研究，评估了气道高反应性和肺功能纵向变化之间的关系。肺功能每年进行评估肺功能，健康和家庭信息获得标准化问卷调查。在第六次和第十二次年度调查之间，至少两次测量了非特异性气道对使用冰点以下空气的正常呼吸过度通气的反应性。在任何给定的调查中，显著的支气管收缩反应定义为（[激发前FEV 1-激发后FEV 1/pre-FEV 1）≥ 0.13，该值可识别10%的人群。根据不同调查中确定的反应一致性，将受试者分为“从不”、“总是”或“不一致”反应者。如果受试者的Δ FEV 1/FEV 1的最大调查间差异> 0.18，则进一步将其归类为“不稳定”，否则归类为“不稳定”。使用针对先前肺功能水平、性别、生长变量和吸烟暴露进行调整的马尔可夫型自回归模型来对FEV 1、FEF 25/2 -75和FVC的生长进行建模。总体而言，135名（73%）受试者从未对冷空气挑战作出反应，6名（3%）总是作出反应，43名（24%）在一次但不是所有情况下作出反应。FEF 25、2 - 75的水平和水平的增加率在不一致和总是应答者中显著较低。相比之下，FVC水平最高，并且在始终应答者中增加最多。在不稳定的受试者中，FEF 25、2 - 75和FEV 1的增长率均降低。当哮喘患者被排除在分析之外时，这些影响仍然存在。这些数据表明，气道反应性的程度和变异性与特定的肺功能变化有关。此外，气道高反应性可能与生长期儿童的气道功能和肺部大小的不同影响有关。
The relationship between airway hyperresponsiveness and longitudinal change in lung function was assessed in a population-based sample of 184 children and young adults observed over a maximum span of 12 yr. Pulmonary function was assessed annually with spirometry, and health and household information was obtained with standardized questionnaires. Nonspecific airway responsiveness to eucapneic hyperventilation with subfreezing air was measured on at least two occasions between the sixth and twelfth annual surveys. At any given survey, a significant bronchoconstrictor response was defined as ([prechallenge FEV1-postchallenge FEV1/pre-FEV1) ⩾ 0.13, a value that identified 10% of the population. Subjects were classified as “never,” “always,” or “inconsistent” responders according to the consistency of responsiveness determined in different surveys. Subjects were classified further as “labile” if their maximal survey-to-survey difference in ΔFEV1/FEV1was ⩾ 0.18, and as “nonlabile” otherwise. A Markov-type autoregressive model that adjusts for previous pulmonary function level, sex, growth variables, and smoking exposures was used to model growth of FEV1, FEF25\2-75, and FVC. Overall, 135 (73%) of subjects never responded to the cold air challenge, six (3%) always responded, and 43 (24%) responded on one but not all occasions. Levels and rates of increase in level of FEF25\2-75were significantly lower in the inconsistent and always responders. In contrast, levels of FVC were greatest and increased most in the always responders. In labile subjects, both FEF25\2-75and FEV1growth rates were reduced. These effects persisted when asthmatics were excluded from the analyses. These data suggest that both the degree and variability of airway responsiveness are associated with specific pulmonary function changes. Furthermore, airway hyperresponsiveness may be associated with different effects on airway function and lung size in growing children.
登录
查看更多内容
哮喘患者等二氧化碳冷空气挑战的日内和日间重现性。
影响因子：
14.2
作者：
P. Tessier;A. Cartier;J. L'archevêque;H. Ghezzo;R. Martin;J. Malo
通讯作者：
J. Malo
儿童哮喘后肺部变大：气腔扩大的结果。
DOI：
--
发表时间：
1985
期刊：
Australian and New Zealand Journal of Medicine
影响因子：
--
作者：
I. Greaves;H. Colebatch
通讯作者：
H. Colebatch
DOI：
--
发表时间：
1967
期刊：
British Journal of Preventive and Social Medicine
影响因子：
--
作者：
J. Lunn;J. Knowelden;A. Handyside
通讯作者：
A. Handyside
评估氦氧最大呼气流量曲线在儿童肺部疾病流行病学研究中的有用性。
DOI：
10.1164/ajrccm/136.4.834
发表时间：
1987
期刊：
The American review of respiratory disease
影响因子：
--
作者：
Redline,S;Tager,IB;Castile,RG;Weiss,ST;Barr,M;Speizer,FE
通讯作者：
Speizer,FE
男性吸烟者和戒烟者的支气管对吸入组胺的反应性和 FEV1 年下降率。
影响因子：
10
作者：
RG Taylor;H. Joyce;BG Simonsson;G. F. Rego;A. R. Rojo
通讯作者：
A. R. Rojo