Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan
Airborne particulate matter (PM2.5) and the prevalence of allergic conjunctivitis in Japan
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DOI：
10.1016/j.scitotenv.2014.04.057
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发表时间：
2014-07-15
影响因子：
9.8
通讯作者：
Matsubara, Masao
中科院分区：
文献类型：
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作者：
Mimura, Tatsuya;Ichinose, Takamichi;Matsubara, Masao
目的：暴露于直径小于2.5 μ m的颗粒物（PM2.5）与哮喘和呼吸道症状有关，但对PM2.5对过敏性结膜炎的影响知之甚少。本研究的目的是研究的关联PM2.5与门诊就诊过敏性结膜炎。方法：我们进行了一个时间序列分析之间的关联门诊就诊过敏性结膜炎和PM2.5水平从5月至7月（非花粉季节）和8月至10月（秋季花粉季节）在2012年。空气污染数据（包括PM2.5、氧化剂、一氧化氮、二氧化氮、氮氧化物、一氧化碳、甲烷、非甲烷碳氢化合物和总碳氢化合物的水平）和每日天气状况（温度、风速和湿度）的数据在位于东京中心的监测站收集。我们计算了每周平均的每日门诊量，以及空气污染和天气数据，并使用每周平均值进行分析。结果：过敏性结膜炎的门诊就诊次数与PM2.5水平之间存在显著相关性（r = 0.62，p = 0.0177），而8 - 11月的门诊就诊次数与任何评估变量之间均未发现相关性。多变量分析还显示，PM2.5是5月至7月门诊就诊人数的显著预测因素（比值比-= 9.05，p = 0.0463），而8月至10月门诊就诊人数无显著预测因素。5 ~ 7月PM2.5与湿度呈负相关（r =-0.53，p = 0.0499）。结论：PM2.5可能在非花粉季节过敏性结膜炎的发病中起作用。PM2.5和过敏性结膜炎之间的这种关联可能对过敏性疾病具有广泛的公共卫生意义。(C)2014爱思唯尔有限公司版权所有。
Objective: Exposure to particulate matter less than 2.5 mu m in diameter (PM2.5) is associated with asthma and respiratory symptoms, but little is known about the influence of PM2.5 on allergic conjunctivitis. The purpose of this study was to examine the association of PM2.5 with outpatient attendance for allergic conjunctivitis.Methods: We conducted a time-series analysis of the association between outpatient attendance for allergic conjunctivitis and PM2.5 levels from May to July (non-pollen season) and from August to October (the autumnal pollen season) in 2012. Air pollution data (including the levels of PM2.5, oxidants, nitric oxide, nitrogen dioxide, nitrogen oxide, carbon monoxide, methane, non-methane hydrocarbons, and total hydrocarbons) and data on the daily weather conditions (temperature, wind speed, and humidity) were collected at a centrally located monitoring station in Tokyo. We calculated weekly average values for the daily number of outpatient visits, as well as the air pollution and weather data, and used the weekly average values for analysis.Results: There was a significant association between the number of outpatient visits for allergic conjunctivitis and the PM2.5 level (r = 0.62, p = 0.0177) from May to July, while no correlation was found between the number of outpatient visits and any variable assessed from August to November. Multivariate analysis also showed that PM2.5 was a significant predictor of the number of outpatient visits from May to July (odds ratio -= 9.05, p = 0.0463), while there were no significant predictors of the number of outpatient visits from August to October. From May to July, PM2.5 showed a negative correlation with humidity (r = -0.53, p = 0.0499).Conclusions: These findings suggest a possible role of PM2.5 in the development of allergic conjunctivitis during the non-pollen season. This association between PM2.5 and allergic conjunctivitis may have broad public health implications in relation to allergic diseases. (C) 2014 Elsevier B.V. All rights reserved.