Neuronal code for extended time in the hippocampus
Neuronal code for extended time in the hippocampus
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DOI：
10.1073/pnas.1214107109
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发表时间：
2012-11-20
影响因子：
11.1
通讯作者：
Leutgeb, Jill K.
中科院分区：
文献类型：
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作者：
Mankin, Emily A.;Sparks, Fraser T.;Leutgeb, Jill K.
事件发生的时间可以成为自传体记忆的一部分。在支持这种记忆的大脑结构中，应该存在一种神经代码，代表事件发生的时间或时间。在这里，我们描述了海马体中的神经元编码机制，该机制可用于表示在数小时至数天的间隔内的经验的新近性。当相同的事件在这样的时间段后重复时，海马CA1细胞群的活动模式随着时间距离的增加而逐渐不同。尽管如此，空间和背景的编码仍然保留。与CA1相比，海马CA3细胞群的放电模式是高度可重复的，与时间间隔无关，因此随着时间的推移提供了稳定的记忆代码。因此，在CA1而不是CA3的神经元活动模式包括一个代码，可以用来区分时间间隔在一个扩展的规模，与行为研究表明，CA1区是有选择地需要在这样的时间编码一致。
The time when an event occurs can become part of autobiographical memories. In brain structures that support such memories, a neural code should exist that represents when or how long ago events occurred. Here we describe a neuronal coding mechanism in hippocampus that can be used to represent the recency of an experience over intervals of hours to days. When the same event is repeated after such time periods, the activity patterns of hippocampal CA1 cell populations progressively differ with increasing temporal distances. Coding for space and context is nonetheless preserved. Compared with CA1, the firing patterns of hippocampal CA3 cell populations are highly reproducible, irrespective of the time interval, and thus provide a stable memory code over time. Therefore, the neuronal activity patterns in CA1 but not CA3 include a code that can be used to distinguish between time intervals on an extended scale, consistent with behavioral studies showing that the CA1 area is selectively required for temporal coding over such periods.