Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease.
Inhibition of interleukin-1 by an interleukin-1 receptor antagonist prevents graft-versus-host disease.
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DOI：
10.1182/blood.v78.8.1915.1915
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发表时间：
1991-10
期刊：
影响因子：
20.3
通讯作者：
P. McCarthy;S. Abhyankar;S. Neben;Gale D. Newman;C. Sieff;R. Thompson;Steven;-J.;Burakoff
中科院分区：
文献类型：
--
作者：
P. McCarthy;S. Abhyankar;S. Neben;Gale D. Newman;C. Sieff;R. Thompson;Steven;-J.;Burakoff
移植物抗宿主病（GVHD）是异基因骨髓移植（BMT）的主要并发症。在临床和实验性GVHD中已经注意到炎性单核因子如肿瘤坏死因子α（TNF α）的失调。我们目前的证据表明，白细胞介素-1（IL-1），另一种炎症单核细胞因子，是一个重要的调解人的GVHD。在患有GVHD的小鼠的皮肤中，IL-1 α基因以及TNF α基因的表达增加。通过体内施用IL-1受体拮抗剂（IL-1 ra）抑制IL-1功能可降低GVHD的免疫抑制和死亡率，而不损害造血干细胞的植入。因此，GVHD似乎是一种全身性炎症过程，其中单核因子，特别是IL-1，似乎是重要的介质。通过IL-1 ra抑制IL-1代表了理解和控制GVHD的新方法。
Graft-versus-host disease (GVHD) is the major complication of allogeneic bone marrow transplantation (BMT). Dysregulation of inflammatory monokines such as tumor necrosis factor alpha (TNF alpha) has been noted in both clinical and experimental GVHD. We present evidence that interleukin-1 (IL-1), another inflammatory monokine, is an important mediator of GVHD. Expression of the gene for IL-1 alpha as well as the gene for TNF alpha is increased in the skin of mice with GVHD. Inhibition of IL-1 function by the in vivo administration of IL-1 receptor antagonist (IL-1ra) reduces the immunosuppression and mortality of GVHD without impairing the engraftment of hematopoietic stem cells. GVHD thus appears to be a systemic inflammatory process in which monokines, especially IL-1, appear to be important mediators. Inhibition of IL-1 by IL-1ra represents a novel approach to the understanding and control of GVHD.