Canine olfaction as an alternative to analytical instruments for disease diagnosis: understanding 'dog personality' to achieve reproducible results
Canine olfaction as an alternative to analytical instruments for disease diagnosis: understanding 'dog personality' to achieve reproducible results
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DOI：
10.1088/1752-7163/aa5524
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发表时间：
2017-03-01
影响因子：
3.8
通讯作者：
Pleil, Joachim
中科院分区：
文献类型：
--
作者：
Hackner, Klaus;Pleil, Joachim
最近的文献已经吹捧使用犬嗅觉作为诊断工具，用于识别临床前疾病状态，特别是来自生物介质样品的癌症和感染。研究表明，结果多种多样，从几乎完美的区分，一直到基本上随机的结果。这种差异不太可能是一个检测问题;狗已经被证明有非常敏感的鼻子，这已经被它们用于跟踪，炸弹探测和搜索和救援所证明。然而，与分析仪器相比，狗容易厌倦，疲劳，饥饿和外部干扰。这些挑战在临床环境中特别重要，在这种环境中，任务重复是很有价值的，但对狗来说并不像在户外追逐气味那样有趣。这里要解决的问题是，面对行为和反应的变化，如何利用狗简单地嗅出疾病的内在敏感性和简单性。
Recent literature has touted the use of canine olfaction as a diagnostic tool for identifying pre-clinical disease status, especially cancer and infection from biological media samples. Studies have shown a wide range of outcomes, ranging from almost perfect discrimination, all the way to essentially random results. This disparity is not likely to be a detection issue; dogs have been shown to have extremely sensitive noses as proven by their use for tracking, bomb detection and search and rescue. However, in contrast to analytical instruments, dogs are subject to boredom, fatigue, hunger and external distractions. These challenges are of particular importance in a clinical environment where task repetition is prized, but not as entertaining for a dog as chasing odours outdoors. The question addressed here is how to exploit the intrinsic sensitivity and simplicity of having a dog simply sniff out disease, in the face of variability in behavior and response.