NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vivo
NMDA receptor-dependent and -independent long-term depression in the CA1 region of the adult rat hippocampus in vivo
复制标题
DOI：
10.1016/s0028-3908(96)90015-5
复制
发表时间：
1997-03-01
影响因子：
4.7
通讯作者：
Bashir, ZI
中科院分区：
文献类型：
--
作者：
Kemp, N;Bashir, ZI
我们研究了不同的刺激参数，试图在体外诱导成年大鼠海马区CA1区的长期抑郁(LTD)。900个1赫兹刺激不能诱导LTD，1赫兹450对(50毫秒刺激间隔)900个刺激可诱导显著且稳定的N-甲基-D-天冬氨酸(NMDA)受体依赖性LTD。然而，900对1赫兹的刺激仅能部分阻断NMDA受体拮抗剂D-2-氨基-5-磷酸戊酸(AP5)对LTD的抑制作用。(C)1997年爱思唯尔科学有限公司。
We have investigated different stimulus parameters in an attempt to induce long-term depression (LTD) in the CA1 region of adult rat hippocampus in vitro. Whereas 900 stimuli delivered at 1 Hz failed to induce LTD, 900 stimuli when delivered as 450 pairs (50 msec inter-stimulus interval) at 1 Hz induced significant and stable N-methyl-D-aspartate (NMDA) receptor-dependent LTD. However, 900 paired stimuli at 1 Hz induced LTD which was only partly blocked by the NMDA receptor antagonist, D-2-amino-5-phosphonopentanoate (AP5). (C) 1997 Elsevier Science Ltd.