EFFECTS OF AGE AND SEX ON PATTERN ELECTRORETINOGRAMS AND VISUAL EVOKED-POTENTIALS
EFFECTS OF AGE AND SEX ON PATTERN ELECTRORETINOGRAMS AND VISUAL EVOKED-POTENTIALS
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DOI：
10.1016/0168-5597(87)90023-2
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发表时间：
1987-05-01
期刊：
影响因子：
--
通讯作者：
CONE, S
中科院分区：
文献类型：
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作者：
CELESIA, GG;KAUFMAN, D;CONE, S
本文对112名20 ~ 75岁正常人同时进行了图形视网膜电图（P-ERG）和视觉诱发电位（VEP）检查。两个大小的支票对着15“和31”被用作刺激。加权回归分析用于确定哪些变量，性别或年龄，是显着的。P-ERG的a、B波潜伏期随年龄增长而递增，但无性别差异。对于15“和31”检查，该效果具有统计学显著性。31“检查引起的VEP没有统计学显著的老化效应。然而，老化影响N70、P100以及B波至N70和B波至P100之间的峰间期。在15“和31”检查中，女性的VEP潜伏期较短。P-ERG和VEP的同时记录表明，在视网膜水平上，年龄是一个主要变量。对a波和B波的影响主要是由于随年龄增长的光学变化，而仅部分是由于神经元视网膜回路的年龄变化。年龄对不同大小刺激的VEP的影响不同。其原因是随着个体年龄的增长，从视神经到视觉皮层的视觉通路中的随机神经元细胞损失。性别之间的VEP数据的差异可能与解剖大小和激素的影响。
Pattern-electroretinograms (P-ERGs) and visual evoked potentials (VEPs) were simnultaneously recorded in 112 normal individuals aged 20-75. Two-sized checks subtending 15'' and 31'' were used as stimuli. A weighted regression analysis was used to determine which of the variables, sex or age, was significant. The latency of the a and b wave of the P-ERGs showed a progressive increase with age but no difference between sexes. The effect was statistically significant for both 15'' and 31'' checks. There was no statistically significant aging effect for VEPs elicited by 31'' checks. Aging, however, affected N70, P100, and the interpeak interval between b wave to N70 and b wave to P100 for responses to 15'' checks. Shorter VEP latencies were noted in females for both 15'' and 31'' checks. The simultaneous recording of P-ERGs and VEPs has demonstrated that aging is a major variable at the retinal level. The effects on the a and b waves are mostly due to optic changes with aging and only partially to aging changes in the neuronal retinal circuitry. The effect of aging on VEPs is different for different size stimuli. The cause is a random neuronal cell loss in the visual pathways from the optic nerve to the visual cortex as the individual ages. The difference in VEP data between sexes may be related to anatomical size and hormonal influences.