EUS-guided hydrogel microparticle injection in a cadaveric model.
EUS-guided hydrogel microparticle injection in a cadaveric model.
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在尸体模型中进行 EUS 引导的水凝胶微粒注射。
DOI：
10.1002/acm2.13266
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发表时间：
2021-06
影响因子：
2.1
通讯作者：
Shin EJ
中科院分区：
文献类型：
--
作者：
Kim SH;Ding K;Rao A;He J;Bhutani MS;Herman JM;Narang A;Shin EJ
在胰头癌放射治疗期间，减少胃肠道毒性的一种潜在方法是在胰头（HOP）和十二指肠之间创造一个物理空间。迄今为止，已经有早期的关于超声内镜（EUS）引导的水凝胶注射到HOP和十二指肠之间的界面以增加胰腺周围放射治疗空间的可行性的报道。我们的目的是评估EUS引导水凝胶注射在尸体模型胰腺周围界面创造空间的技术可行性。对三个未固定的尸体标本进行了基线腹部计算机断层扫描（CT）。采用线性阵列EUS和19G细针抽吸（FNA）将水凝胶经十二指肠注射到HOP和十二指肠之间的界面。沿着HOP的长度重复这个过程。术后进行CT成像和大体解剖，以确定水凝胶的定位，并测量HOP与十二指肠之间的距离。所有尸体都成功地接受了EUS引导下的水凝胶注射。1、2、3号尸体分别注射9.5、27、10毫升水凝胶；沿HOP方向，胰周间隙形成的最大尺寸分别为11.77、13.20和12.89 mm。在EUS和术后CT图像上，水凝胶注射清晰地显示为高回声大泡，没有任何伪影。我们证明了EUS引导的水凝胶递送是可行的，并且在尸体模型中它增加了胰腺周围的空间。聚乙二醇（PEG）水凝胶在EUS和CT上清晰可见，无明显伪影。这可能会导致胰腺癌的新治疗方法。
A potential method to reduce gastrointestinal toxicity during radiation therapy in pancreatic head cancer is to create a physical space between the head of the pancreas (HOP) and the duodenum. To date, there have been early reports on the feasibility of endoscopic ultrasound (EUS)‐guided hydrogel injection into the interface between the HOP and the duodenum to increase the peri‐pancreatic space for radiotherapy. We aimed to evaluate the technical feasibility of EUS‐guided hydrogel injection for the creation of space at the peri‐pancreatic interface in a cadaveric model. Baseline abdominal computerized tomography (CT) was performed on three unfixed cadaveric specimens. The hydrogel was injected transduodenally into the interface between the HOP and duodenum using linear‐array EUS and a 19G needle for fine needle aspiration (FNA). This procedure was repeated along the length of the HOP. CT imaging and gross dissection were performed after the procedure to confirm the localization of the hydrogel and to measure the distance between the HOP and the duodenum. All cadavers underwent successful EUS‐guided injection of the hydrogel. Cadavers 1, 2, and 3 were injected with 9.5, 27, and 10 cc of hydrogel, respectively; along the HOP, the formation of the peri‐pancreatic space was a maximum size of 11.77, 13.20, and 12.89 mm, respectively. The hydrogel injections were clearly visualized as hyperechoic bullae during EUS and on post‐procedure CT images without any artifacts in all cases. We demonstrated that EUS‐guided delivery of hydrogel is feasible, and that it increases the peri‐pancreatic space in a cadaveric model. The polyethylene glycol (PEG) hydrogel was clearly visible on EUS and CT, without significant artifacts. This may lead to new treatment approaches for pancreatic carcinomas.
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影响因子：
2.1
作者：
Boissier, Romain;Udrescu, Corina;Ruffion, Alain
通讯作者：
Ruffion, Alain
DOI：
10.1016/j.ijrobp.2011.02.034
发表时间：
2012-04-01
影响因子：
7
作者：
Noyes, William R.;Hosford, Charles C.;Schultz, Steven E.
通讯作者：
Schultz, Steven E.
影响因子：
6.8
作者：
Kozlowski, A;Charles, SA;Harris, JM
通讯作者：
Harris, JM
影响因子：
2.5
作者：
Kedia P;Gaidhane M;Kahaleh M
通讯作者：
Kahaleh M
影响因子：
254.7
作者：
Siegel, Rebecca L.;Miller, Kimberly D.;Jemal, Ahmedin
通讯作者：
Jemal, Ahmedin