HEREDITARY FACTORS IN CANCER - STUDY OF 2 LARGE MIDWESTERN KINDREDS
HEREDITARY FACTORS IN CANCER - STUDY OF 2 LARGE MIDWESTERN KINDREDS
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DOI：
10.1001/archinte.117.2.206
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发表时间：
1966-01-01
影响因子：
--
通讯作者：
KRUSH, AJ
中科院分区：
文献类型：
--
作者：
LYNCH, HT;SHAW, MW;KRUSH, AJ
对两个可能有亲缘关系的中西部大家族的研究表明，每个家族都有很高的癌症发病率。这包括范围广泛的恶性肿瘤，包括每个家庭成员中的多原发癌。恶性肿瘤的解剖部位的多样性以及传播方式也惊人地相似。对这些家系肿瘤遗传的可能性进行了讨论。虽然常染色体显性遗传很可能解释了家系的发现，但细胞质和/或病毒因素的作用也必须被考虑。
Study of 2 large midwestern kindred which are possibly related revealed a high incidence of carcinoma in each. This included a wide spectrum of malignant neoplasms including multiple primary carcinomas in members of each family. The variety of anatomic sites of malignancies as well as the transmission was also strikingly similar. Possibilities for the inheritance of neoplasms in these families was discussed. While autosomal dominant inheritance most likely explains the pedigree findings, the role of cytoplasmic and/or viral factor must also be considered.