Piezoelectric BioMEMS Cantilever for Measurement of Muscle Contraction and for Actuation of Mechanosensitive Cells.
Piezoelectric BioMEMS Cantilever for Measurement of Muscle Contraction and for Actuation of Mechanosensitive Cells.
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DOI：
10.1557/mrc.2019.129
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发表时间：
2019-12
影响因子：
1.9
通讯作者：
Hickman JJ
中科院分区：
文献类型：
--
作者：
Coln EA;Colon A;Long CJ;Sriram NN;Esch M;Prot JM;Elbrecht DH;Wang Y;Jackson M;Shuler ML;Hickman JJ
设计并制造了一种压电生物医学微机电系统（bioMEMS）悬臂装置，作为肌肉组织收缩的传感元件或作为向细胞施加机械力的致动器。通过监测氮化铝压电悬臂梁上培养的ipsc衍生心肌细胞收缩时产生的电信号，证明了压电悬臂梁的传感能力。通过对压电悬臂梁施加电脉冲并通过光学检测方法观察弯曲来演示驱动。这种压电悬臂装置被设计成集成到人体芯片系统中。
A piezoelectric biomedical microelectromechanical system (bioMEMS) cantilever device was designed and fabricated to act as either a sensing element for muscle tissue contraction or as an actuator to apply mechanical force to cells. The sensing ability of the piezoelectric cantilevers was shown by monitoring the electrical signal generated from the piezoelectric aluminum nitride in response to the contraction of iPSC-derived cardiomyocytes cultured on the piezoelectric cantilevers. Actuation was demonstrated by applying electrical pulses to the piezoelectric cantilever and observing bending via an optical detection method. This piezoelectric cantilever device was designed to be incorporated into body-on-a-chip systems.