Dopamine efflux in the rat nucleus accumbens evoked by dopamine receptor stimulation in the entorhinal cortex is modulated by oestradiol and progesterone
Dopamine efflux in the rat nucleus accumbens evoked by dopamine receptor stimulation in the entorhinal cortex is modulated by oestradiol and progesterone
复制标题
内嗅皮层多巴胺受体刺激引起的大鼠伏隔核中的多巴胺流出受到雌二醇和黄体酮的调节
作者：
T. Saigusa;K. Takada;Simon C. Baker;R. Kumar;J. Stephenson
本研究比较了内嗅皮层多巴胺受体刺激对丘脑核多巴胺释放的影响，通过清醒Sprague-道利大鼠体内微透析测定，有和没有雌二醇和孕酮引发。阿扑吗啡的非选择性多巴胺受体刺激减少了延髓核中的多巴胺释放，通过将顺式氟噻吨注射到内嗅皮质中来防止这种作用。选择性D1受体刺激SKF 38393增加多巴胺的释放，而选择性D2受体刺激quinpirole不影响多巴胺的释放。雌二醇和孕酮的联合给药增强了对阿扑吗啡的反应，并阻止了对SKF 38393的反应。单一激素给药对阿扑吗啡反应的影响表明，这种调节主要是由于孕酮的雌二醇增强作用。高[K+]的实验表明，这些激素的影响主要是在内嗅皮层。目前的实验表明，多巴胺能调制的传输在皮质-纹状体回路连接颞叶和前额皮质的调节雌二醇和孕酮。人类该系统的功能障碍可能会引起情感和认知症状，如果这些症状是由产后雌激素和孕激素浓度下降引发的，则可能构成产后精神病的核心病理生理学。Synapse 25：37-43，1997.© 1997 Wiley利斯公司
This study compared the effects of dopamine receptor stimulation in the entorhinal cortex on dopamine release in the nucleus accumbens, measured by in vivo microdialysis in conscious Sprague‐Dawley rats, with and without oestradiol and progesterone priming. Nonselective dopamine receptor stimulation with apomorphine reduced dopamine release in the nucleus accumbens, an effect which was prevented by injection of cis‐flupenthixol into the entorhinal cortex. Selective D1 receptor stimulation with SKF38393 increased dopamine release, whereas selective D2 receptor stimulation with quinpirole did not affect dopamine release. Combined administration of oestradiol and progesterone potentiated the response to apomorphine and prevented the response to SKF38393. The effects of single hormone administration on the response to apomorphine suggested that the modulation was primarily due to oestradiol enhancing effects of progesterone. Experiments with high [K+] suggested these hormonal effects were exerted predominantly in the entorhinal cortex. The present experiments have demonstrated that dopaminergic modulation of transmission in a cortico‐striatal loop linking temporal and prefrontal cortex is regulated by oestradiol and progesterone. Dysfunction in this system in humans may give rise to affective and cognitive symptoms which may, if initiated by a postpartum fall in oestrogen and progesterone concentrations, constitute the core pathophysiology of puerperal psychosis. Synapse 25:37–43, 1997. © 1997 Wiley‐Liss, Inc.