Vector host-feeding preferences drive transmission of multi-host pathogens: West Nile virus as a model system
Vector host-feeding preferences drive transmission of multi-host pathogens: West Nile virus as a model system
复制标题
DOI：
10.1098/rspb.2011.1282
复制
发表时间：
2012-03
期刊：
影响因子：
--
通讯作者：
J. Simpson;P. Hurtado;J. Medlock;Goudarz Molaei;T. Andreadis;A. Galvani;M. Diuk-Wasser
中科院分区：
文献类型：
--
作者：
J. Simpson;P. Hurtado;J. Medlock;Goudarz Molaei;T. Andreadis;A. Galvani;M. Diuk-Wasser
感染多种物种的病媒病原体的季节性流行在生态上是复杂的，很难预测。病原菌在寄主群落内的传播潜力取决于寄主物种维持和传播病原菌的相对能力，以及影响寄主与媒介之间接触率的生态因素。越来越多的证据表明，许多媒介的强烈取食偏好表明，病原体经历的宿主群落可能与当地宿主群落非常不同。我们建立了西尼罗河病毒(WNV)在四个地点的经验性传播模型，该模型使用一个媒介物种(淡色库蚊)和偏好和非偏好禽类宿主。我们用CX测量了美洲知更鸟(Turdus Migratorius)强烈的摄食偏好。以Cx所占的比例量化。知更鸟的血粉与它们的丰度(摄食指数)的关系。该模型准确地预测了西尼罗河病毒在CX的流行情况。在四个地点中有三个发现了蚊子。敏感性分析表明，摄食偏好是影响CX西尼罗河病毒感染强度和感染高峰时间的最大参数。并确定了传播的阈值摄食指数。我们的发现表明，宿主偏好诱导的接触异质性是多物种宿主群落中媒介传播病原体流行病的关键中介因素，应纳入多宿主传播模型。
Seasonal epizootics of vector-borne pathogens infecting multiple species are ecologically complex and difficult to forecast. Pathogen transmission potential within the host community is determined by the relative abilities of host species to maintain and transmit the pathogen and by ecological factors influencing contact rates between hosts and vectors. Increasing evidence of strong feeding preferences by a number of vectors suggests that the host community experienced by the pathogen may be very different from the local host community. We developed an empirically informed transmission model for West Nile virus (WNV) in four sites using one vector species (Culex pipiens) and preferred and non-preferred avian hosts. We measured strong feeding preferences for American robins (Turdus migratorius) by Cx. pipiens, quantified as the proportion of Cx. pipiens blood meals from robins in relation to their abundance (feeding index). The model accurately predicted WNV prevalence in Cx. pipiens at three of four sites. Sensitivity analysis revealed feeding preference was the most influential parameter on intensity and timing of peak WNV infection in Cx. pipiens and a threshold feeding index for transmission was identified. Our findings indicate host preference-induced contact heterogeneity is a key mediator of vector-borne pathogen epizootics in multi-species host communities, and should be incorporated into multi-host transmission models.