Emotions and family factors in childhood asthma: psychobiologic mechanisms and pathways of effect.
Emotions and family factors in childhood asthma: psychobiologic mechanisms and pathways of effect.
复制标题
儿童哮喘的情绪和家庭因素：心理生物学机制和影响途径。
DOI：
10.1159/000073785
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发表时间：
2003
影响因子：
--
通讯作者：
Wood,BeatriceL
中科院分区：
文献类型：
--
作者：
Miller,BruceD;Wood,BeatriceL
Asthma is a complex clinical syndrome characterized by variable airflow obstruction, bronchial hyperresponsiveness, airway edema, and eosinophilic and lymphocytic inflammation. Triggers include allergens, infections, exercise, cold air, and emotions. Mechanisms of airway constriction include both immune/inflammatory pathways and cholinergic/vagal pathways [1]. Asthma is one of the most common chronic diseases of childhood, affecting 4.8 million children in the United States [2]. Among children with chronic medical conditions, asthma is the most common cause for hospitalization and school absence [3]. Asthma morbidity and mortality are increasing, despite new medical treatment regimens [4]. Much research has focused on poor treatment adherence as a factor affecting asthma morbidity and mortality [5–11]. Although adherence is clearly important, there is also an increasing body of clinical and empirical findings implicating emotions and stress as contributing factors in asthma morbidity [12, 13] and mortality [14, 15]. It is likely that the effects of emotional distress on asthma are meditated in part by adherence. However, psychobiologic pathways and mechanisms linking stress and emotions with disease activity in asthma have also been posited [15–22]. There is abundant research focusing on adherence as a contributing factor in asthma morbidity, but to date direct psychobiologic links are less well researched.
