Tea and tea polyphenols in cancer prevention
Tea and tea polyphenols in cancer prevention
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DOI：
10.1093/jn/130.2.472s
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发表时间：
2000-02-01
影响因子：
4.2
通讯作者：
Lee, MJ
中科院分区：
文献类型：
--
作者：
Yang, CS;Chung, JY;Lee, MJ
茶（Camellia sinensis）和茶成分对癌症形成的抑制作用已在许多实验室的涉及不同器官部位的不同动物模型中得到证实。然而，茶对人类癌症的可能预防作用尚不清楚。一个关键问题是，从动物研究中获得的信息是否适用于人类，因为可能存在物种差异，或者动物研究中使用的茶量与人类消耗的茶量存在差异。本文将讨论动物研究的结果以及可能适用于人类癌症预防的可能的癌症抑制机制。为了为更定量分析茶的致癌作用提供依据，对血液、尿液和组织样本中茶多酚的含量进行了分析，并研究了茶多酚的药代动力学特性。对细胞系的研究表明，茶多酚影响信号转导途径，抑制细胞增殖并诱导细胞凋亡，但有效浓度通常远高于血液和组织中观察到的浓度。在这些领域进行更多的机制研究将有助于我们了解茶的抑制致癌作用，并为评估茶对人类致癌作用的影响提供背景。
The inhibitory action of tea (Camellia sinensis) and tea components against cancer formation has been demonstrated in different animal models involving different organ sites in many laboratories. The possible preventive activity of tea against cancer in humans, however, is not clear. A critical question is whether the information obtained from animal studies is applicable to humans because of possible species differences or the difference in the quantity of tea used in animal studies and that consumed by humans. This article will discuss the results from animal studies and possible cancer inhibitory mechanisms that might be applicable to human cancer prevention. To provide a basis for more quantitative analyses of the effect of tea on carcinogenesis, the levels of tea polyphenols in blood, urine and tissue samples have been analyzed, and the pharmacokinetic properties of tea polyphenols studied. Studies with cell lines have demonstrated that tea polyphenols affect signal transduction pathways, inhibit cell proliferation and induce apoptosis, but the effective concentrations are usually much higher than those observed in blood and tissues. More mechanistic studies in these areas will help us to understand the inhibitory action of tea against carcinogenesis and provide background for evaluating the effects of tea consumption on human carcinogenesis.