Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects
Allergy medication in Japanese volunteers: treatment effect of single doses on nocturnal sleep architecture and next day residual effects
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DOI：
10.1185/030079906x112660
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发表时间：
2006-07-01
影响因子：
2.3
通讯作者：
Kumagi, Yuji
中科院分区：
文献类型：
--
作者：
Boyle, Julia;Eriksson, Malin;Kumagi, Yuji
目的：评价两种组胺H-1受体拮抗剂对夜间睡眠结构及次日认知功能和精神运动能力的急性影响。方法：采用单点、随机、双盲、3向交叉研究方法，比较18名20~55岁健康日本志愿者单剂量服用扑尔敏(6 Mg)、非索非那定(120 Mg)和安慰剂的疗效。志愿者入驻3天，每段时间至少有5天的淘汰期。三个处理均于2300h开始给药。采用多导睡眠图测量患者的夜间睡眠时间为23.00h~07.00h。结果：与安慰剂相比，氯苯那敏延长了小鼠入睡潜伏期和快速眼动睡眠(REM)睡眠潜伏期(P
Objectives: To evaluate the acute effects of two histamine H-1-receptor antagonists on nocturnal sleep architecture and on next day cognitive function and psychomotor performance.Methods: This was a single-site, randomized, double-blind, 3-way crossover study, comparing the effects of a single dose of chlorpheniramine (6mg), fexofenadine (120mg)and placebo in 18 healthy (male and female) Japanese volunteers aged 20-55 years. Volunteers were resident for 3 days and each period was separated by a minimum 5-day washout period. The three treatments were administered at 23.00h. Overnight sleep was measured from 23.00h to 07.00h using polysomnography. Residual effects were studied at 07.00h and 9.00h the next morning, with the latency to sleep (sleep latency test) measured at 09.30h.Results: Compared with placebo, chlorpheniramine increased the latencies to sleep onset and rapid eye movement ( REM) sleep (p