Highly Selective Uptake and Release of Charged Molecules by pH-Responsive Polydopamine Microcapsules
Highly Selective Uptake and Release of Charged Molecules by pH-Responsive Polydopamine Microcapsules
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pH 响应型聚多巴胺微胶囊高度选择性地摄取和释放带电分子
DOI：
10.1002/mabi.201100061
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发表时间：
2011-09-09
影响因子：
4.6
通讯作者：
Zhou, Feng
中科院分区：
文献类型：
--
作者：
Liu, Qinze;Yu, Bo;Zhou, Feng
报道了小分子药物通过Pdop微胶囊的渗透的系统研究。通过在聚苯乙烯微球上氧化聚合多巴胺，然后用THF除去核来制备两性离子Pdop微胶囊。选择罗丹明6 G、甲基橙子和茜素红作为不同电荷的探针染料。负载量受pH和染料浓度的影响。通过控制pH值可以实现带电分子通过Pdop微胶囊的高度选择性和单向吸收和释放：在低pH下，Pdop颗粒掺入阳离子染料（罗丹明6 G）;在高pH下，它们掺入阴离子染料（甲基橙子和茜素红）。在每种情况下，摄取都是高度选择性的。
A systematic study of the permeation of small molecules through Pdop microcapsules is reported. The zwitterionic Pdop microcapsules are prepared by oxidative polymerization of dopamine on polystyrene microspheres followed by core removal with THF. Rhodamine 6G, methyl orange and alizarin red are chosen as differently charged probing dyes. The loading amount is affected by pH and dye concentration. Highly selective and unidirectional uptake and release of charged molecules through Pdop microcapsules can be achieved by controlling pH value: at low pH, the Pdop particles incorporate cationic dye (rhodamine 6G); at high pH, they incorporate anionic dyes (methyl orange and alizarin red). In each case, the uptake is highly selective.