Impairments in reaching during reversible inactivation of the distal forelimb representation of the motor cortex in the cat.
Impairments in reaching during reversible inactivation of the distal forelimb representation of the motor cortex in the cat.
复制标题
猫运动皮层远端前肢可逆失活期间，伸手能力受损。
DOI：
10.1016/0304-3940(91)90057-z
复制
发表时间：
1991
影响因子：
2.5
通讯作者：
Ghez,C
中科院分区：
文献类型：
--
作者：
Martin,JH;Ghez,C
我们报告的变化，在猫的动作任务的表现局灶性失活的运动皮层（MCx）的远前肢区的喙外侧亚区蝇蕈醇微量注射。动物们把手伸进一个圆柱形的靶子里去拿一口食物。运动包括不同的升降机和前推力阶段，随后的食物被抓住和检索。在单独的试验块中，在肢体的路径中插入障碍物。撞击引起了立即的补偿性轨迹改变以绕过障碍物，并且在随后的试验中，引起了自适应轨迹改变以避免撞击。失活产生了三个主要缺陷：（1）未补偿的瞄准偏差到目标上方的位置;（2）抓握和食物取回的协调性丧失;（3）轨迹适应性受损，以避免肢体与障碍物的碰撞。因此，局灶性失活的远端前肢地区的MCx产生的所有前肢关节的控制紊乱。轨迹适应的障碍和无法补偿瞄准偏差表明MCx在运动学习中很重要。
We report changes in the performance of a prehension task in the cat following focal inactivation of the rostrolateral subregion of the distal forelimb area of motor cortex (MCx) produced by muscimol microinjection. Animals reached into a cylindrical target to retrieve a morsel of food. Movements consisted of distinct lift and forward thrust phases following which the food was grasped and retrieved. In separate blocks of trials an obstacle was inserted in the path of the limb. Impact evoked an immediate compensatory trajectory change to bypass the obstruction and, on subsequent trials, an adaptive trajectory change to avoid impact. Inactivation produced three major defects: (1) uncompensated aiming biases to a location above the target; (2) loss of coordination of the grasp and food retrieval; and (3) impairment in trajectory adaptation to avoid impact of the limb with an obstacle. Thus, focal inactivation of the distal forelimb area of MCx produced disordered control of all forelimb joints. The impairment in trajectory adaptation and failure to compensate for aiming biases suggests that the MCx is important in motor learning.