Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
Peripheral noxious stimulation induces phosphorylation of the NMDA receptor NR1 subunit at the PKC-dependent site, serine-896, in spinal cord dorsal horn neurons
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DOI：
10.1111/j.1460-9568.2004.03506.x
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发表时间：
2004-07-01
影响因子：
3.4
通讯作者：
Woolf, CJ
中科院分区：
文献类型：
--
作者：
Brenner, GJ;Ji, RR;Woolf, CJ
N-甲基-D-天冬氨酸受体（NMDAR）有助于脊髓中的中枢致敏和疼痛超敏反应的产生。NMDAR功能受包括磷酸化在内的翻译后修饰的调节，这被认为是其参与脊髓疼痛超敏反应产生的基础。现在，我们表明，一个有害的热刺激施加到大鼠后爪诱导磷酸化的NMDAR NR 1亚基在蛋白激酶C（PKC）依赖的网站，丝氨酸-896，在浅表背角神经元。NRII丝氨酸-896的磷酸化在未处理大鼠的背角浅层中基本上不存在，但是，
The N-methyl-D-aspartate receptor (NMDAR) contributes to central sensitization in the spinal cord and the generation of pain hypersensitivity. NMDAR function is modulated by post-translational modifications including phosphorylation, and this is proposed to underlie its involvement in the production of pain hypersensitivity in the spinal cord. We now, show that a noxious heat stimulus applied to the rat hindpaw induces phosphorylation of the NMDAR NR1 subunit at a protein kinase C (PKC)-dependent site, serine-896, in superficial dorsal horn neurons. Phosphorylation of NRII serine-896 is essentially absent in the superficial dorsal horn laminae of naive rats, but, there is rapid (