Planar cell polarity genes, Celsr1-3, in neural development
Planar cell polarity genes, Celsr1-3, in neural development
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DOI：
10.1007/s12264-012-1232-8
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发表时间：
2012-06-01
影响因子：
5.6
通讯作者：
Zhou, Libing
中科院分区：
文献类型：
--
作者：
Feng, Jia;Han, Qi;Zhou, Libing
Flamingo是平面细胞极性的核心基因之一，其蛋白属于一个独特的钙粘附素亚家族。与经典的钙粘蛋白不同，经典的钙粘蛋白由几个细胞外钙粘蛋白重复序列、一个跨膜区和一个与连环蛋白结合的细胞质片段组成，而果蝇火烈鸟有七个跨膜片段和一个细胞质尾巴，没有连环蛋白结合序列。在果蝇中，火烈鸟在控制上皮极性和神经元形态发生方面具有多效性作用。火烈鸟的三个哺乳动物同源基因Celsr1-3在神经系统中广泛表达。最近的研究表明，Celsr1-3在神经发育中发挥着重要作用，例如在轴突引导、神经元迁移和纤毛极性方面。Celsr1-3单基因敲除小鼠表现出不同的表型，但这些基因之间存在协同作用。
flamingo is among the 'core' planar cell-polarity genes, protein of which belongs to a unique cadherin subfamily. In contrast to the classic cadherins, composed of several extracellular cadherin repeats, one transmembrane domain and one cytoplasmic segment linked to catenin binding, Drosophila Flamingo has seven transmembrane segments and a cytoplasmic tail with no catenin-binding sequence. In Drosophila, Flamingo has pleotropic roles in controlling epithelial polarity and neuronal morphogenesis. Three mammalian orthologs of flamingo, Celsr1-3, are widely expressed in the nervous system. Recent work has shown that Celsr1-3 play important roles in neural development, such as in axon guidance, neuronal migration, and cilium polarity. Celsr1-3 single-gene knockout mice exhibit different phenotypes, but there are cooperative interactions among these genes.