Ejaculation frequency and subsequent risk of prostate cancer
Ejaculation frequency and subsequent risk of prostate cancer
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DOI：
10.1001/jama.291.13.1578
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发表时间：
2004-04-07
影响因子：
120.7
通讯作者：
Giovannucci, E
中科院分区：
文献类型：
--
作者：
Leitzmann, MF;Platz, EA;Giovannucci, E
背景性活动被假设在前列腺癌的发展中起作用，但流行病学数据实际上仅限于病例对照研究，这可能容易产生偏倚，因为前列腺癌患者的回忆可能会因前列腺恶性肿瘤或正在进行的治疗而扭曲。设计、设置和参与者：一项前瞻性研究，使用来自健康专业人员随访研究的随访数据（1992年2月1日至2000年1月31日）29342名年龄在46至81岁之间的美国男性，他们在1992年的一份自填问卷中提供了关于射精频率的历史信息，并在2000年之前每2年回答一次随访问卷。通过要求参与者报告他们在20 - 29岁、40 - 49岁和过去一年（1991年）内每月射精的平均次数来评估射精频率。主要结果测量总前列腺癌的发病率。953例器官局限性病例，147例晚期前列腺癌病例。大多数种类的射精频率与前列腺癌的风险无关。然而，高射精频率与总前列腺癌风险降低有关。在20至29岁年龄段，男性报告每月射精21次或更多与男性报告每月射精4至7次的多变量相对风险为0.89（95%置信区间[CI]，0.73-1.10）;年龄40 - 49岁，0.68（95% CI，0.53-0.86）;前一年，0.49（95% CI，0.27-0.88）;一生平均值，0.67（95% CI，0.51 -0.89）。器官局限性前列腺癌也观察到类似的相关性。射精频率与晚期前列腺癌风险无统计学显著相关性。结论我们的研究结果表明，射精频率与前列腺癌风险增加无关。
Context Sexual activity has been hypothesized to play a role in the development of prostate cancer, but epidemiological data are virtually limited to case-control studies, which may be prone to bias because recall among individuals with prostate cancer could be distorted as a consequence of prostate malignancy or ongoing therapy.Objective To examine the association between ejaculation frequency, which includes sexual intercourse, nocturnal emission, and masturbation and risk of prostate cancer.Design, Setting, and Participants Prospective study using follow-up data from the Health Professionals Follow-up Study (February 1, 1992, through January 31, 2000) of 29342 US men aged 46 to 81 years, who provided information on history of ejaculation frequency on a self-administered questionnaire in 1992 and responded to follow-up questionnaires every 2 years to 2000. Ejaculation frequency was assessed by asking participants to report the average number of ejaculations they had per month during the ages of 20 to 29 years, 40 to 49 years, and during the past year (1991).Main Outcome Measure Incidence of total prostate cancer.Results During 222426 person-years of follow-up, there were 1449 new cases of total prostate cancer, 953 organ-confined cases, and 147 advanced cases of prostate cancer. Most categories of ejaculation frequency were unrelated to risk of prostate cancer. However, high ejaculation frequency was related to decreased risk of total prostate cancer. The multivariate relative risks for men reporting 21 or more ejaculations per month compared with men reporting 4 to 7 ejaculations per month at ages 20 to 29 years were 0.89 (95% confidence interval [CI], 0.73-1.10); ages 40 to 49 years, 0.68 (95% CI, 0.53-0.86); previous year, 0.49 (95% CI, 0.27-0.88); and averaged across a lifetime, 0.67(95% CI, 051-0.89). Similar associations were observed for organ-confined prostate cancer. Ejaculation frequency was not statistically significantly associated with risk of advanced prostate cancer.Conclusions Our results suggest that ejaculation frequency is not related to increased risk of prostate cancer.